Double-blind studies of tolerance to praziquantel in Japanese patients with Schistosoma japonicum infections.

The first clinical trials of praziquantel against Schistosoma japonicum infections in Japan were planned to assess tolerance only. Three double-blind studies against placebo involving a total of 51 patients were conducted with dosages of praziquantel of 1 × 20 mg/kg body weight, 2 × 20 mg/kg, 3 × 20 mg/kg given on one day.