Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma |
| |
Authors: | Stefan S. Bielack Rudolf Erttmann Guido Looft Christine Purfürst Günther Delling Kurt Winkler Günther Landbeck Cooperative Osteosarcoma Study Group COSS) |
| |
Affiliation: | (1) Abteilung für pädiatrische Hämatologie und Onkologie, Universitäts-Kinderklinik Hamburg-Eppendorf, Martinistrasse 52, D-2000 Hamburg 20, Federal Republic of Germany;(2) Pathologisches Institut, Universitäts-Krankenhaus Hamburg-Eppendorf, Martinistrasse 52, D-2000 Hamburg 20, Federal Republic of Germany |
| |
Abstract: | Summary Preoperative chemotherapy according to the COSS 86 protocol, including two courses of cisplatin, was used for high-risk osteosarcoma. Patients were randomised to receive either intraarterial (i.a.) or intravenous (i.v.) cisplatin infusions. As measured by flameless atomic absorption spectroscopy (FAAS), platinum (Pt) levels in serum, ultrafiltrate, and urine did not show a decrease in systemic drug availability with i.a. administration. Turmors were surgically removed 3 weeks after the last cisplatin dose and analysed for Pt content and response to chemotherapy. A correlation could not be demonstrated between Pt levels in tumor tissue samples and the mode of CDDP application or extent of tumor cell destruction.This work was supported by the Hamburger Krebsgesellschaft and the Bundesministerium für Forschung und Technologie |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|