| D-半乳糖衰老大鼠下颌下腺超微结构的改变 |
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| 引用本文： | 于海忠,赵淑敏,葛志华. D-半乳糖衰老大鼠下颌下腺超微结构的改变[J]. 河北医药, 2009, 31(11): 1287-1288 |
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| 作者姓名： | 于海忠 赵淑敏 葛志华 |
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| 作者单位： | 河北省承德市政府机关门诊部口腔科,067000;承德医学院,067000;承德医学院附属医院,067000 |
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| 摘 要： | 目的探讨实验性衰老大鼠下颌下腺超微结构的改变。方法用D-半乳糖制造衰老大鼠模型。2组大鼠经4%多聚甲醛＋2.5%戊二醛灌注固定,常规方法制备下颌下腺超薄切片,透射电镜下观察主要细胞的超微结构。结果正常组大鼠颗粒曲管（GCT）及腺细胞内粗面内质网、线粒体、高尔基复合体发达,粗面内质网网腔均匀、表面附有较多核糖体颗粒;核膜清晰,染色质分布均匀,可见丰富的质膜内褶。模型组GCT及腺细胞核固缩,染色质浓缩,部分细胞膜断裂,可见线粒体肿胀及嵴断裂,粗面内质网减少、有核糖体脱落现象。结论D-半乳糖模型大鼠下颌下腺超微结构发生明显衰老改变。
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| 关 键 词： | D-半乳糖 大鼠 下颌下腺 超微结构 |
The ultrastructural changes of submandibular gland in D-galactose aging rats |
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| YU Haizhong,ZHAO Shumin,GE Zhihua. The ultrastructural changes of submandibular gland in D-galactose aging rats[J]. Hebei Medical Journal, 2009, 31(11): 1287-1288 |
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| Authors: | YU Haizhong ZHAO Shumin GE Zhihua |
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| Affiliation: | YU Haizhong,ZHAO Shumin,GE Zhihua.Department of Stomatology,Chengde Government Clinical Department,Hebei,Chengde 067000,China |
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| Abstract: | Objective To observe the tissue ultrastructural changes of submandibular gland in D-galactose aging rats.Methods D-galactose senescence model was used in this research.The submandibular glands were taken out after the rats being infused with 4% polyformaldehyde + 2.5% glutaraldehyde,ultrathin sections were observed under transmission electron microscope to investigate the ultrastructurral changes in the main cells.Results In control group,there were abundant organelles,such as mitochondrion,rough endoplasmi... |
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| Keywords: | D-galactose rats submandibular gland ultrastructure |
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