具有NO释放作用的葛根素衍生物的设计与合成

目的设计合成具有NO释放作用的新型葛根素衍生物,以期通过NO与葛根素的协同作用,增强衍生物在心血管方面的活性。方法将有机硝酸酯通过不同长度的碳链与葛根素7/4′-酚羟基连接,或通过哌嗪连接子与葛根素7/4′-酚羟基连接,得到7-单取代或7-、4′-双取代的葛根素的硝酸酯衍生物。结果与结论共合成了16个未见文献报道的新化合物,其结构经1H-NMR及MS谱确证。

Design and synthesis of NO releasing puerarin derivatives

Aim To design and synthesize new puerarin derivatives with NO releasing activity to further improve the cardiovascular activity of puerarin. Method The nitrate was linked to the 7/4’-OH directly or through piperazinyl group to give ten 7-O-substituted puerarin derivatives and six 7,4’-O-disubstituted puerarin derivatives . Results and conclusions The structures of sixteen puerarin derivatives which have not been reported in literature were identified by ESI-MS and ¹H-NMR.