糖代谢异常和糖尿病患者脉压的研究

目的:脉压与心脑血管疾病相关,糖代谢异常和2型糖尿病也是心脑血管疾病的危险因子,但是脉压与糖代谢异常、2型糖尿病的关系未见在我国人群中的研究报道。方法:对2 420例常规健康体检者进行血浆总胆固醇、甘油三酯、收缩压、舒张压、脉压和体重指数(BMI)测定,观察脉压与糖代谢异常和2型糖尿病的关系。为了避免年龄对脉压的影响,我们将所有被检查者以年龄分为3组(40~54岁组、55~69岁组和≥70岁组)。结果:40~54岁者脉压、收缩压、舒张压、BMI和甘油三酯在糖代谢异常和2型糖尿病组明显升高(P<0.01),总胆固醇在各组之间差异无显著性(P>0.05)。55~69岁者只有脉压在糖代谢异常和2型糖尿病组中明显升高(P<0.05)。年龄≥70岁组中,所有观察指标在各组之间差异均无显著性(P>0.05)。结论:脉压在年龄<70岁的糖代谢异常和2型糖尿病患者中升高。脉压升高预示着心脑血管疾病危险因素的存在。

The study on pulse pressure in impaired glucose metabolism and type 2 diabetes patients

Objective： Pulse pressure is related to cardiovascular diseases. Impaired glucose metabolism （IGM） and type 2 diabetes are also the risk factors to cardiovascular diseases, but the relationship between pulse pressure and IGM, type 2 diabetes has not been investigated in Chinese population. Method： A total of 2 420 subjects who attented a routine health examination were recruited and tested for cholesterol, triglyceride, systolic blood pressure, diastolic pressure, pulse pressure, and body mass index （BMI）. The relationship of pulse pressure with IGM and type 2 diabetes was studied. In order to avoid the effect of age on pulse pressure, we stratified all subjects into three groups （40-54, 55-69 and over 70 year old）. Result： Pulse pressure, systolic blood pressure, diastolic blood pressure, BMI and triglyceride were significantly higher in IGM and type 2 diabetes patients in the age between 40 and 54 year old（ P 〈 0.01 ）. Total cholesterol level was not significantly differed among the three groups（ P 〉 0.05）. In the age between 55 and 69 year old, only pulse pressure was significantly increased in the IGM and diabetes patients（ P 〈 0.05）. In the age group of over 70 year old, all the observed index were not significantly differed among the three groups （P 〉 0.05）. Conclusion： The pulse pressure is increased in the patients of IGM or type 2 diabetes under the age of 70 year old. The increased pulse pressure may be a marker to identify individuals at risk for cardiovascular diseases.