| 月见草油乳剂的生物利用度研究 |
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| 引用本文： | 杜建平,陈济民.月见草油乳剂的生物利用度研究[J].沈阳药科大学学报,1991(2). |
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| 作者姓名： | 杜建平 陈济民 |
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| 作者单位： | 沈阳药学院生物药剂研究室，沈阳药学院生物药剂研究室 88届研究生 |
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| 摘 要： | 本文采用大鼠和健康志愿者,对月见草油乳剂,以其中主要有效成分γ-亚麻酸为指标,进行了生物利用度研究。大鼠灌胃绝对生物利用度为73.21%;幽门静脉注射绝对生物利用度为89.91%;相对灌胃给予月见草油的相对生物利用度为176.6%.健康志愿者相对口服月见草油胶丸的相对生物利用度为173.5%. 实验结果说明,对于月见草油来说,乳剂是一种好剂型。
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| 关 键 词： | 月见草油 γ-亚麻酸 生物利用度 乳剂 |
A STUDY ON THE BIOAVAILABILITY OF EVENING PRIMROSE OIL |
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| Du Jianping Chen Jimin.A STUDY ON THE BIOAVAILABILITY OF EVENING PRIMROSE OIL[J].Journal of Shenyang Pharmaceutical University,1991(2). |
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| Authors: | Du Jianping Chen Jimin |
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| Institution: | Du Jianping Chen Jimin Department of Biopharmaceutics |
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| Abstract: | Reported in this article is the result of a study on the bioavailability of γ-linolenic acid from evening primrose oil and its emulsion in rats and men. The absolute bioavailability of γ-linolenic acid taken orally in the form of evening primrose oil emulsion is 73.21% in rats. The relative bioavailability of γ-linolenic acid when the oral administration of evening primrose oil emulsion is compared with that evening primrose oil (or its soft gelatin capsule), is 176.6% in rats(or 173.5% in men). |
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| Keywords: | Evening primrose oiI γ-Linolenic acid Bioavailability Emulsion |
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