妊高征患者血小板活化与凝血纤溶检测指标的临床应用

目的:观查妊高征患者血小板计数、血小板活化及凝血纤溶等指标变化,探讨妊高征与凝血纤溶系统的关系。方法:采用血细胞自动分析仪和酶联免疫吸附试验(ELISA),对95例妊高征患者,30例正常晚期孕妇和30例正常非孕妇进行血小板计数(PLT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)、血小板а-颗粒膜蛋白(GMP-140)、抗凝血酶Ⅲ(AT-Ⅲ)、凝血酶-抗凝血酶复合物(TAT)、纤维蛋白原(Fib)、和D-二聚体(D-Dimer)进行测定。结果:与正常非妊娠组和正常晚期妊娠组相比,妊高征组PLT、AT-Ⅲ显著降低(P<0.01),MPV、PDW、GMP-140、TAT、Fib和D-二聚体显著增高。结论:妊高征凝血功能的变化是一个从高凝到高凝纤溶平衡,再到纤溶亢进的DIC前状态的过程,以上指标能较好反映妊高征患者病情症状。

Clinical application of detection of platelet activation and coagulation and fibrinolysis in the pregnancy induced hypertention patients

Objective:To explore the relationship between PIH and coagulation and fibrinolysis systeme by studying the changes of platelet count,platelet activation,coagulation and fibrinolysis.Methods:The PLT,MPV,PDW,GMP-140 AT-Ⅲ,TAT,Fib and D-dimer were tested and analyzed in 95 cases of PIH,30 cases of normal late pregnancy women and 30 cases of normal non-pregnancy women.Results:The result showed that PLT,AT-Ⅲ were obviously lower and MPV,PDW,Fib,TAT and D-dimer was obviously raiser in the PIH group than in the normal late pregnancy women group and the normal non-pregnancy women.There was a statistically significant difference in the three groups.Conclusion:The change of coagulation and fibrinolysis in the PIH is a pre-DIC process from hypercoagulation state to a balance of hypercoagulation and high fibrinolysis,then to high fibrinolysis.The detection of above indexes can better reflect PIH.