| 脆性组氨酸三联体基因与喉癌研究进展 |
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| 引用本文： | 吴春芳,李玲香.脆性组氨酸三联体基因与喉癌研究进展[J].医学综述,2008,14(8):1192-1194. |
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| 作者姓名： | 吴春芳 李玲香 |
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| 作者单位： | 内蒙古医学院附属医院耳鼻咽喉科,呼和浩特,010050 |
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| 摘 要： | 肿瘤的发生、发展受多种基因调控。脆性组氨酸三联体基因(FHIT)是近几年发现的抑癌基因,目前大量研究证实,脆性组氨酸三联体基因定位于3p14.2,其抑癌作用可能与调控细胞周期、诱导细胞凋亡、二腺苷三磷酸水解酶、微管蛋白、泛素结合酶等有关。文章就FHIT基因的结构、抑制肿瘤的作用、机制及其在喉癌中缺失及异常的相关研究近况予以综述。
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| 关 键 词： | 脆性组氨酸三联体基因 抑癌基因 喉癌 |
| 文章编号： | 1006-2084(2008)08-1192-03 |
| 修稿时间： | 2007年9月2日 |
Research Progress in the Relationship between Fragile Histidine Triad Gene and Laryngeal Carcinoma |
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| WU Chun-fang,LI Ling-xiang.Research Progress in the Relationship between Fragile Histidine Triad Gene and Laryngeal Carcinoma[J].Medical Recapitulate,2008,14(8):1192-1194. |
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| Authors: | WU Chun-fang LI Ling-xiang |
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| Institution: | Department of Otolaryngology;Affiliated Hospital Inner Mongolia Medical College;Hohhot 010050 China |
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| Abstract: | The occurrence and progress of tumor are regulated by many genes.The fragile histidine triad gene(FHIT)is a new-found gene which can suppress the progressive growth of tumor recently.It has identified at chromosome 3p14.2 by positional cloning.The mechanisms for inactivating the gene have been revealed to deletions,cell cycle retardation hydrolysis of 5',5'-P1,P3-triphosphate hydrolase(Ap3A),tubulin,and ubiquitin conjugase.This article will review the structure of FHIT gene and summarize its function and ... |
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| Keywords: | Fragile histidine triad gene Tumor suppression genes Laryngeal neoplasms |
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