新生儿病理性黄疸相关指标的检测

目的检测新生儿病理性黄疸患者的相关指标。方法对解放军第一七四医院产科2006年1月—2008年12月收治的129例新生儿病理性黄疸患者，进行血型鉴定、胆红素检测和抗人球蛋白（Coombs）试验，评价这些指标与新生儿黄疸的相关性。结果新生儿病理性黄疸患者总胆红素和间接胆红素均高于参考值10倍以上；血型为O型新生儿与非O型病理性黄疸发生率比较，差异有统计学意义（P〈0．05），新生儿病理性黄疸抗人球蛋白试验阳性率为36．43％，且阳性者血型为非O型的占91．47％。结论间接胆红素增高直接影响总胆红素的水平及临床表现，这与新生儿生理特征有一定关系；非O型新生儿较容易发生病理性黄疸，提示新生儿溶血症可以引起新生儿病理性黄疸；Coombs试验检测不规则抗体有助于鉴别引起病理性黄疸的因素。

Detection of Relevant Indicators of Neonatal Pathological Jaundice

[ Objective] To detect the relevant indicators of neonatal pathological jaundice. [ Methods] Totally 129 cases of pathologic neonatal jaundice in PLA No. 174 Hospital from January 2006- December 2008 were selected for blood group identification, bihrubin detection and Coombs test. The relevance of neonatal jaundice with these indicators was evaluated. [ Results] Total bihrubin and indirect bilirubin of patients with pathological neonatal jaundice were over 10 times higher than the reference value ; The incidence of pathological jaundice between patients of O type and non-O type was significantly different （ P 〈 0.05 ）. Pathological neonatal jaundice Coombs test positive rate was 36.43%, and positive patients with non-O blood type accounted for 91.47%. [ Conclusion] Indirect bilirubin direct impacts the increasing of total bihrubin levels and clinical manifestations , which has a certain relation with physi- ological characteristics of newborns; non-O type newborns are more easy to get pathological neonatal jaundice which indicates hemolyric disease can induce pathological jaundice of newborn; Coombs test for detection of irregular antibodies will help to identify inducing factors of pathologic jaundice.