Neck metastasis in patients with T1-2 supraglottic cancer |
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Authors: | Tomoyasu Tachibana Yorihisa Orita Hidenori Marunaka Sei-ichiro Makihara Misato Hirai Yuka Gion Kana Ikegami Kentaro Miki Takuma Makino Yasuyuki Noyama Yasutoshi Komatsubara Miyuki Kimura Tadashi Yoshino Kazunori Nishizaki Yasuharu Sato |
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Institution: | 1. Department of Otolaryngology, Himeji Red Cross Hospital, 12-1 Shimoteno 1-Chome, Himeji City, 670-8540 Hyogo, Japan;2. Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama City, 700-8558 Okayama, Japan;3. Department of Otolaryngology, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Kita-Ku, Okayama City, 701-1154 Okayama, Japan;4. Department of Otolaryngology, Kagawa Rosai Hospital, 3-3-1 Joto-Cho, Marugame City, 763-8502 Kagawa, Japan;5. Department of Otolaryngology, Okayama Saiseikai General Hospital, 1-17-18 Ifuku-Cho, Kita-Ku, Okayama City, 700-0013 Okayama, Japan;6. Department of Otolaryngology Head and Neck Surgery and Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama City, 700-8558 Okayama, Japan;g. Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan |
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Abstract: | ObjectivesUnlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer.MethodsThis retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015.ResultsOf 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age <70 years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer.ConclusionRelatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis. |
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Keywords: | Supraglottic cancer Sublocation Prognosis Neck metastasis Human papillomavirus |
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