| 葛根素对去卵巢大鼠心肌超微结构的影响 |
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| 引用本文： | 吴洪海,黄竞,杨林,吴庚华,朱永泽,卜平.葛根素对去卵巢大鼠心肌超微结构的影响[J].实用临床医药杂志,2011,15(9):1-3,7. |
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| 作者姓名： | 吴洪海 黄竞 杨林 吴庚华 朱永泽 卜平 |
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| 作者单位： | 扬州大学医学院,江苏,扬州,225001 |
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| 基金项目： | 江苏省科技厅基础实施建设计划 |
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| 摘 要： | 目的探讨葛根素对去卵巢大鼠心肌的影响,以期为临床研究更年期心脏疾病提供形态学依据。方法雌性健康SD大鼠32只,分为假手术组、动物模型组、雌激素组和葛根素组。光镜下观看心肌组织学变化,透射电镜下观察心肌超微结构的变化。结果去卵巢后,大鼠心肌细胞核周隙不规则扩张,染色质浓集成块;线粒体嵴融合、消失、排列紊乱、卷曲呈髓鞘样变化,嵴间隙扩张、明显空泡化;闰盘间隙不规则增宽。雌激素、葛根素使上述病变减轻。结论葛根素对去卵巢大鼠心脏有保护作用。
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| 关 键 词： | 大鼠 葛根素 雌激素 心肌 |
Effect of puerarin on myocardial ultrastructure in ovariectomized rats |
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| WU Hong-hai,HUANG Jing,YANG Lin,WU Geng-hua,ZHU Yong-ze,BU Ping.Effect of puerarin on myocardial ultrastructure in ovariectomized rats[J].Journal of Clinical Medicine in Practice,2011,15(9):1-3,7. |
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| Authors: | WU Hong-hai HUANG Jing YANG Lin WU Geng-hua ZHU Yong-ze BU Ping |
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| Institution: | WU Hong-hai,HUANG Jing,YANG Lin,WU Geng-hua,ZHU Yong-ze,BU Ping(Medical College of Yangzhou University,Yangzhou,Jiangsu,225001) |
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| Abstract: | Objective To provide the morphological basis for clinical application,the study investigated effects of puerarin on myocardium in ovariectomized rats.Methods Thirty-two healthy female SD rats were divided into 4 groups: sham operation group,model group,estrogen group,puerarin group.Myocardium was observed under light microscope and ultrastructure changes of myocardial cells were analyzed under the electron microscopy.Results After ovariectomy,myocardial nuclear membrane gap irregularly expanded,chromatin co... |
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| Keywords: | rat puerarin estradiol myocardium |
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