| 首次脑梗死后患者认知功能障碍的多因素相关研究 |
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| 引用本文： | 刘涵,程言博,樊红彬,耿德勤.首次脑梗死后患者认知功能障碍的多因素相关研究[J].实用临床医药杂志,2011,15(9). |
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| 作者姓名： | 刘涵 程言博 樊红彬 耿德勤 |
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| 作者单位： | 徐州医学院附属医院,神经内科,江苏,徐州,221006 |
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| 基金项目： | 国家自然科学基金资助项目，江苏省政府重点室开发课题资助项目 |
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| 摘 要： | 目的探讨首次脑梗死后患者发生认知功能障碍的相关因素。方法采用CT或MRI确定首次脑梗塞患者282例,所有患者均为右利手。病灶部位:额叶53例,顶叶45例,颞叶50例,枕叶43例,丘脑33例,基底节174例,小脑30例,脑干51例;测定病灶体积;采用中文版蒙特利尔认知评估量表(MOCA)、汉密顿抑郁量表(HAMD)评定患者的认知功能。结果①额叶、顶叶、颞叶、枕叶、丘脑、基底节梗死与认知功能障碍的发生具有相关性(P<0.05)。小脑、脑干梗死与认知功能障碍无相关性。②病灶体积大小与认知功能障碍呈显著相关性(P<0.05)。③MOCA总分与HAMD分值呈显著性负相关(P<0.05)。认知功能正常组与异常组的HAMD得分有显著性差异(P<0.05)。④首次卒中后有认知功能损害者呈低文化水平特征,有长期大量饮酒史患者认知功能障碍有显著性异常(P<0.05)。结论认知功能障碍是首次脑梗死患者的常见并发症,认知功能障碍与卒中部位及体积有关,病灶体积大者认知功能障碍严重,教育水平低、长期大量饮酒及抑郁患者更易发生认知障碍。
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| 关 键 词： | 脑梗死 认知功能障碍 多因素分析 |
Study on the related factors of cognitive impairment in cerebral infarction patients with first attack |
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| LIU Han,CHENG Yan-bo,FAN Hong-bin,GENG De-qin.Study on the related factors of cognitive impairment in cerebral infarction patients with first attack[J].Journal of Clinical Medicine in Practice,2011,15(9). |
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| Authors: | LIU Han CHENG Yan-bo FAN Hong-bin GENG De-qin |
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| Institution: | LIU Han,CHENG Yan-bo,FAN Hong-bin,GENG De-qin(The Affiliated Hospital of Xuzhou Medical College,Xuzhou,Jiangsu,221006) |
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| Abstract: | Objective To study the related factors of cognitive impairment in cerebral infarction patients with first attack.Methods The lesion volumes and locations(frontal lobe 53 cases,parietal lobe 45 cases,temporal lobe 50 cases,occipital lobe 43 cases,thalamus 33 cases,basal ganglia 174 cases,cerebellum 30 cases and brainstem 8 cases) in patients(n=282) were measured by using CT/MRI techniques(all the patients were right-handed);Cognitive function were tested with Montreal Cognitive Assessment(MOCA) and Hamilton ... |
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| Keywords: | cerebral infarction cognitive dysfunction multiple factors |
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