乳腺癌的淋巴道转移与癌细胞中MMP-9表达的相关性

目的 :观察乳腺癌组织中基质金属蛋白酶 - 9(Matrixmetalloproteinases ,MMP - 9)基因产物表达的情况 ,以探讨MMP - 9在乳腺癌浸润和转移过程中的作用。方法 :采用免疫组织化学SP方法检测 76例乳腺浸润癌中MMP - 9的表达情况。其中无淋巴结转移 36例 ,有淋巴结转移 4 0例。结果 :MMP - 9在淋巴结转移和无淋巴结转移两组之间的差异具有显著性 (P <0 .0 5 )。转移组淋巴结转移灶癌细胞MMP - 9的阳性表达例多于原发灶 ,但无显著性差异。结论 :乳腺癌的淋巴道转移与MMP - 9的表达具有显著相关性 ,检测MMP - 9蛋白表达将有助于判断乳腺癌的转移潜能及预后。

The expression of MMP - 9 protein is associated with lymph node metastasis of breast carcinoma

Objective: To investigate the relationship between the lymph node metastasis of breast carcinoma and the expression of MMP-9 protein and find the effect of the protein during the course of invasion and metastasis of breast carcinoma. Methods: Expression of MMP-9 protein is examined immunohistochemistrily in 76 cases of breast carcinomas including 40 cases with lymph node metastasis and 36 cases without lymph node metastasis. Results: There is a significant difference in MMP-9 expressions between the lymph node metastasis group and the non- lymphnode- metastasis group. There is no significant difference of MMP-9 expression between the primary tumors and the metastasis lesions, but the cases of MMP-9 positive expression in the metastasis focus are more than those of primary focus. Conclusions: The lymph node metastasis is associated with the expression of MMP-9 in breast carcinoma.