电针对单纯性肥胖瘦素及脂联素的影响

目的:探讨针刺治疗单纯性肥胖的作用机制。方法:将60例单纯性肥胖患者随机分为对照组、电针组、手针组,后两组隔天治疗1次,9次为1疗程,对照组不采用任何治疗。3个疗程后观察疗效。选穴分为两组:1)梁丘、血海、支沟、外关等;2)公孙、内庭、丰隆等。两组穴位交替使用。电针组采用电针(疏密波,强度2~5 mA,频率0.8~3 Hz)双侧天枢、腹结等穴,轮流给予。手针组在电针的相同穴位上行平补平泻手法,每10 min捻转1次,每次1 min,频率100~120次/min,留针30 min。治疗前后采血对患者瘦素及脂联素值以酶联免疫法进行测定。结果:电针组与手针组瘦素值较治疗前均下降(P<0.01),电针组瘦素值与手针组比较有显著差异(P<0.01)。电针组与手针组脂联素值治疗后均明显升高(P<0.01,0.05),电针组与手针组比较有显著差异(P<0.05)。对照组上述指标治疗前后的变化无显著性统计学差异。结论:电针和手针均可降低单纯性肥胖病人血中瘦素含量,升高脂联素含量,电针效果明显优于手针。

Effect of Electroacupuncture on Leptin and Adiponectin in Simple Obesity Patients

Objective: To probe into the underlying mechanism of electroacupuncture(EA) for simple obesity patients.Methods: Sixty simple obesity patients were randomly divided into control,manual acupuncture(MA) and EA groups with 20 cases in each group.Acupoint groups 1) Liangqiu(ST 34),Xuehai(SP 10),etc.;2) Gongsun(SP 4),Neiting (ST 44),etc.were punctured respectively for MA groups(once every other day,27 times altogether),and in combination with EA(2-5 mA,0.8-3 Hz,30 min) of bilateral Tianshu(ST 25),Fujie(SP 14),etc.for EA group.Serum leptin(Lep) and adiponectin(Adi) were measured by enzyme linked immunosorbent assay(ELISA).Results: After the treatment,of the 20 cases in control,MA and EA groups,0(0%),0(0%) and 4(20.0%) were cured;0(0%),10(50.0%) and 14(70.0%) were improved remarkably;1(5.0%),7(35.0%) and 1(5.0%) were effective;19(95.0%),3(15.0%) and 1(5.0%) failed,with the effective rates being 5.0%,85.0% and 95.0% separately.The therapeutic effects of both MA and EA groups were significantly higher than that of control group(P<0.01).After the treatment,serum Lep levels in both MA and EA groups decreased significantly,and serum Adi contents of these two groups increased considerably compared with their own basic values of pre-treatment(P<0.05,0.01),and the effects of EA were markedly better than those of MA and control groups(P<0.05).No significant changes were found in Lep and Adi levels in control group(P>0.05).Conclusion: Both EA and manual acupuncture can effectively lower blood Lep content and raise blood Adi in simple obesity patients,which may contribute to its effect in reducing body weight.The effect of EA is significantly superior to that of manual acupuncture in the treatment of simple obesity.