地诺前列酮用于促宫颈成熟和引产临床分析

目的 观察地诺前列酮栓促宫颈成熟和引产的临床效果及其安全性.方法 将孕足月单胎头位、宫颈Bishop评分≤6分、具备阴道分娩条件、既往无子宫瘢痕或无前列腺素过敏、禁忌证初产妇随机分成地诺前列酮栓组和普拉睾酮组,两组用药前及用药后6 h、12 h进行宫颈Bishop评分,比较两组临产率、总产程、分娩方式、产后出血、新生儿结局及不良反应.结果 地诺前列酮栓组用药后6 h、12 h宫颈评分分别是（3.85±0.72）分、（6.79±0.63）分,明显高于对照组[（2.85±0.41）分、（4.26±0.52）分]（t=6.034、15.485,均P＜0.05）.地诺前列酮栓组12 h、24 h临产率（64%、88%）明显高于对照组（24%、48%）.两组产后出血、新生儿结局差异无统计学意义.结论 地诺前列酮栓是一种有效、安全的促宫颈成熟和引产的药物,对母儿无不良影响.

Clinical analysis of 50 cases of dinoprostone suppositories for cervical ripening and labor induction

Objective To study the clinical effect and safety of Dinoprostone suppositories for cervical ripening and labor induction.Methods 50 primiparas with sinsle cephalic term pregnancy.cervical Bishop score≤6 points,with vaginal delivery conditions,no previous uterine scar or prostaglandin allergies or other contraindications were randomly divided into two groups:the dinoprostone suppositories group(observation group)and the sulfuric pula group(control group).The primiparas were administered sulfuric pula keto 200mg/day via intravenous injection for 3 days.Bishop score was assayed in both groups before treatment and 6h.12h after treatment to compare the effect of cervical ripening,labor rates,the total time of labor,mode of delivery,postpartum hemorrhage,neonatal outcomes and adverse reactions.Results Cervical scores were(3.85±0.72)point and(6.79±0.63)point in the observation group 6h and 12h after administration,which were significantly higher than those of control group[(2.85±0.41)point,(4.26±0.52)point](t=6.034,15.485,all P＜0.05).Labor rates of 12h and 24h in the observation group were signitlcandy higher than control group.There Was no significant difference between two groups of neonatal outcomes and postpartum hemorrhage.Conclusion Dinoprostone suppositories sas safe and effective for cervical ripening and labor induction,without adverse effects on mothers and children.