比索洛尔联合甲巯咪唑治疗甲状腺功能亢进症的临床观察

目的 探讨比索洛尔联合甲巯咪唑治疗甲状腺功能亢进症（甲亢）的临床疗效.方法 将100例甲亢患者随机分为对照组（甲巯咪唑治疗）50例和治疗组（比索洛尔联合甲巯咪唑治疗）50例,观察临床疗效和患者血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、高敏促甲状腺激素（S-TSH）的变.结果 治疗组总有效率92.0%,明显高于对照组的78.0%（χ2=3.798,P＜0.05）;两组治疗后TT3、TT4、FT3、FT4含量均低于治疗前（t=2.245,t=2.315,t=2.411,t=2.381,均P＜0.05）,S-TSH含量高于治疗前（t=2.335,P＜0.05）;治疗组甲亢指数积分下降较对照组明显（t=2.312,P＜0.05）.结论 比索洛尔联合甲巯咪唑治疗甲亢能有效改善临床症状,提高疗效.

Clinical observation of bisoprolol combined with methimazole in trealment of hyperthyroidism

Objective To explore the clinical effect and safety of bisoprolol combined with methimazole in treatment of hyperthyroidism.Methods 100 cases with hyperthyroidism were randomly divided into control group (methimazole treatment)50 case.$and treatment group(bisoprolol combined with methimazole treatment)50 cases.The therapeutic effect,serum levels of FT3,FT4 and s-TSH were observed.Results The total effective rate in treatment group 92.0% was significantly higher than 78.0%in control group(χ2=3.798,P＜0.05);The contents of TT3,TT4,FT3,FT4 after treatment were lower than before treatment(t=2.245,2.315,2.411,all P＜0.05);The contents of S-TSH was higher than before treatment(t=2.335,P＜0.05);Hyperthyroidism exponential integral in treatment group decreased significantly than the control group(t=2.312,P＜0.05).Conclusion The bisoprolol combined with methimazole treatment could efficiently improve clinical symptoms,raise therapeutic effect in patients with hyperthyroidism.