急性脑梗死患者血清白细胞介素-6、白细胞介素-8及脂联素水平变化及意义

目的探讨急性脑梗死（ACI）患者的血清IL-6、IL-8及脂联素水平变化。方法采用ELISA法检测98例急性脑梗死患者血清白细胞介素6（IL-6）、白细胞介素8（IL-8）及脂联素含量，并与98例健康对照组比较分析。结果急性脑梗死组血清IL-6、IL-8水平明显升高，而脂联素水平则显著降低，两组差异均有统计学意义（均P〈0．01）；血清IL-6和IL-8水平随梗死体积增大和神经功能缺损程度加重而升高，脂联素水平则降低；血清脂联素水平与血清IL-6、IL-8水平呈显著负相关（r=-0．733，r=-0．715；均P〈0．05），IL-6与IL-8呈显著正相关（r=0．830，P〈0．01）。结论血清IL-6、IL-8及脂联素水平反映了病情轻重及神经功能缺损程度，与脑梗死的临床变化有较密切关系。

Changes and Clinical Significance of serum IL-6 IL-8 and adiponectin in patients with acute cerebral infarction

Objective To explore the clinical significance of changes of serum IL-6,IL-8 and adiponectin in patients with acute cerebral infarction(ACI).Methods Serum IL-6,IL-8 and adiponectin levels were measured by ELISA in 98 patients with ACI and 80 healthy control.Results The ACI group serum IU6 and IL-8 levels were higher than the healthy control group(all P＜0.01),while the level of adiponectin was converse;The levels of serum IL13,IL-18 increased gradually with the increase of the severity and the volume of ACI,while the level of adiponectin was decreased;the serum level of adiponectin was negative correlated with the level of IL-6、IL-8 in patients with ACI (r=0.733,0.715,all P＜0.05),the serum level of IL-6 was positive correlated with the level of IL-8(r=0.830,P＜0.01).Conclusion The serum IL-6,IL-8 and adiponectin could reflected situation of patients and extent of neurologic impairment,which had close relationship with the clinical process of ACI and had significance value to evaluate the pathogenetic condition and prognosis.