病毒性肝炎患者血小板和凝血功能指标联合检测的临床意义

目的 探讨病毒性肝炎患者血小板及凝血功能指标联合检测的临床意义.方法 将310例病毒性肝炎患者分为急性肝炎组、慢性肝炎组、重度肝炎组和肝炎后肝硬化组.另外选择正常体检的健康人80例作为对照组.联合检测其血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）、大型血小板比率（P-LCR）、凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血酶时间（AFTT）、纤维蛋白原浓度（Fbg）.结果 慢性肝炎组、重度肝炎组和肝炎后肝硬化组的PLT、MPV和Fbg与健康对照组差异均有统计学意义（均P〈0.01）.PDW、P-LCR、PT、TT、APTT）与健康对照组差异均有统计学意义（均P〈0.05）.结论 血小板及凝血功能指标的联合检测有助于观察病毒性肝炎的病程进展程度,对于临床治疗及预后有重要意义.

Clinical significance of the joint detection of platelet parameters and coagulation function markers in hepatitis patients

Objective To investigate the clinical significance of the joint detection of platelet parameters and coagulation function markers in hepatitis patients.Methods 310 patients with viral hepatitis were divided into 4 groups:acute hepatitis group,chronic hepatitis group,serious hepatitis group and hepatocirrhosis group.The control group was the 80 healthy examination eligible people.Each group were detected platelet parameters ( PLT), mean platelet volume( MPV),.platelet distribution width( PDW),platelet large cell ratio( P-LCR), prothrombin time( PT) ,activated partial thromboplasin time (APTT ) , thrombin time ( TT) and factorl ( Fbg).Results The levels of PLT,MPV and Fbg were obviously reduced in chronic hepatitis,serious condition chronic hepatitis patients and hepatocirrhosis had significant difference compared with those in the control group (all P < 0.01).Moreover, the levels of PDW,P-LCR,PT,APTT and TT were obviously increased in the four groups compared with the control group(all P <0.05 ).Conclusion The joint detection of platelet parameters and coagulation function markers could help to observe the degree of progression of virus hepatitis,and had important clinical significance for the treatment and prognosis.