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Allergen gene transfer |
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| Authors: | Shau-Ku Huang Kaw-Yan Chua Kue-Hsiung Hsieh |
| Affiliation: | aJohns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA;bDepartment of Pediatrics, Faculty of Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore 119074;;cChang Gung Children's Hospital, 5 Fu-Hsing Street, Kweishan Hsiang, Taoyuan 333, Taiwan, Republic of China |
| Abstract: | DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism involved and optimization of gene transfer/expression systems will assist greatly in proving the clinical utility of this process. |
| Keywords: | Abbreviations: AHR airway hyper-responsiveness CMV cytomegalovirus Der p 5Dermatophagoides pteronyssinus group 5 allergen LacZ β-galactosidase (β-gal) OVA ovalbumin pDNA plasmid DNA Th1 T-helper type 1 cell Th2 T-helper type 2 cell |
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