传统能量限制饮食联合GLP-1 Ras艾塞那肽治疗2型糖尿病伴超重或肥胖患者的临床效果

目的 探讨传统能量限制饮食联合胰高血糖素样肽-1受体激动剂(GLP-1 RAs)艾塞那肽治疗2型糖尿病伴超重或肥胖患者的临床效果.方法 选取2018年6月至2020年10月我院收治的80例2型糖尿病伴超重或肥胖患者作为研究对象,采用计算机生成随机序列的方式,按照1:1的比例将其随机分为对照组和试验组,试验期间,6例患者...

Clinical effect of traditional energy restriction diet combined with GLP-1 RAs exenatide in treatment of type 2 diabetes mellitus with overweight or obesity

Objective To investigate the clinical effect of traditional energy restriction diet combined with glucagon like peptide-1 receptor agonist(GLP-1 RAs) exenatide in the treatment of type 2 diabetes mellitus with overweight or obesity.Methods From June 2018 to Octorber 2020,80 cases of type 2 diabetes mellitus with overweight or obesity were selected as the research objects,using computer-generated random sequences,the patients were randomly divided into control group and experimental group according to the ratio of 1 ∶1.Six patients were withdrawn from the study for personal reasons or poor compliance during experiment.The final analysis included 74 patients,with 37 cases in each group.The control group was given general diabetes diet combined with sulfonylureas,while the experimental group was given energy restriction diet combined with exenatide treatment.After 12 weeks of intervention,the BMI,levels of fasting blood glucose(FBG),glycosylated hemoglobin(HbA1 c),C-peptide,serum insulin,serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were compared between the two groups.Results After intervention,the weight loss effect of the experimental group was better than that of the control group,and the difference was statistically significant(P<0.05).After intervention,the levels of FBG and HbA1 c in the experimental group decreased significantly compared with those before intervention,in which FBG decreased by(0.91 ±2.25) mmol/L and HbA1 c decreased by(0.66±1.01)%,and the differences were statistically significant(P<0.05);the differences of differences of HbA1 c and serum insulin levels before and after intervention between the two groups were statistically significant(P <0.05).After intervention,the levels of serum TC,TG and LDL-C in the experimental group decreased significantly compared with those before intervention,and the decreased levels were(0.46 ±0.74),(0.17±0.29),(0.26±0.50) mmol/L respectively,and the differences were statistically significant(P<0.05).The difference of difference of TC level before and after intervention between the two groups was statistically significant(P<0.05).Conclusion Energy restriction diet combined with exenatide can reduce body weight,improve blood glucose and lipid metabolism in overweight or obese patients with type 2 diabetes,and help control the condition of patients.