生酮饮食添加治疗儿童难治性癫痫的临床效果

目的 探讨生酮饮食(KD)添加治疗儿童难治性癫痫的临床效果.方法 回顾性选取2013年6月至2019年4月于西安市儿童医院神经内科接受KD添加治疗的47例难治性癫痫患儿为研究对象.采用Engel分级评估KD添加治疗的临床疗效,同时评估KD添加治疗的终止原因及不良反应发生情况.结果 接受KD添加治疗的47例患儿中,KD添...

Clinical effect of ketogenic diet addition in the treatment of refractory epilepsy in children

Objective To investigate the clinical effect of ketogenic diet(KD)addition in the treatment of refractory epilepsy in children.Methods Forty seven children with refractory epilepsy who received KD addition therapy in the neurology department of Xi'an children's hospital from June 2013 to April 2019 were selected retrospectively.The clinical efficacy of KD addition therapy was evaluated by Engel classification,and the termination causes and adverse reactions of KD addition therapy were evaluated.Results Among the 47 children who received KD addition therapy,the average age at the beginning of KD addition therapy was(23.8±23.2)months.In the last follow-up before the termination of KD addition therapy,there were 27 cases(57.4%)with effective treatment and 20 cases(42.6%)with ineffective treatment.The median duration of KD addition treatment retention in children with effective treatment was greater than that in children with ineffective treatment,the median duration of the first seizure of epilepsy to the beginning of KD addition treatment was less than that in children with ineffective treatment,and the differences were statistically significant(P<0.05).Among the children with intractable epilepsy treated with KD,a total of 37 cases terminated the treatment.The reasons for termination were ineffective,food refusal,poor compliance,no seizure,gradual transition to normal diet and so on.The side effects of KD addition in the treatment of refractory epilepsy in children were mild,mostly gastrointestinal dysfunction,such as food refusal,diarrhea and constipation.Conclusion KD can be used as a safe and effective treatment scheme for children with refractory epilepsy.Strengthening the KD understanding of clinicians and children's families and early use can improve children's compliance;prolonging the retention time of KD addition treatment may help to improve the efficiency of KD addition in the treatment of refractory epilepsy in children.