STEMI患者恶性室性心律失常与血脂、血糖、同型半胱氨酸代谢的关系

目的 探讨ST段抬高型心肌梗死(STEMI)患者恶性室性心律失常与血脂、血糖、同型半胱氨酸(Hcy)代谢的关系.方法 选择2016年3月至2020年10月在心血管内科接受急诊经皮冠状动脉介入治疗(PCI)的142例STEMI患者作为研究对象,根据PCI后48 h内是否发生恶性室性心律失常将其分为A组(34例,发生恶性室...

Relationship between malignant ventricular arrhythmia and blood lipid,blood glucose and homocysteine metabolism in patients with STEMI

Objective To investigate the relationship between malignant ventricular arrhythmia and blood lipid,blood glucose and homocysteine(Hcy)metabolism in patients with ST-segment elevation myocardial infarction(STEMI).Methods A total of 142 patients with STEMI underwent emergency percutaneous coronary intervention(PCI)in the cardiovascular internal medicine department from March 2016 to October 2020 were selected and divided into group A(34 cases,malignant ventricular arrhythmia)and group B(108 cases,no malignant ventricular arrhythmia)according to whether malignant ventricular arrhythmia occurred within 48 h after PCI.The general clinical information,ECG information and laboratory indexes of the two groups were compared,and the influencing factors of malignant ventricular arrhythmia in patients with STEMI were summarized.Results There were no significant differences in the gender,age,history of hypertension,history of hyperlipidemia,history of smoking,history of drinking,BMI,Killip cardiac function grade,fragmented QRS wave and pathological Q wave between two groups(P>0.05).The proportion of patients with anterior wall myocardial infarction in the group A was higher than that in the group B,and the difference was statistically significant(P<0.05).The levels of hemoglobin and blood potassium in the group A were significantly lower than those in the group B,while the levels of low density lipoprotein cholesterol,blood glucose and blood Hcy were significantly higher than those in the group B,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of triglyceride,high density lipoprotein cholesterol,blood uric acid,creatinine,urea,alanine aminotransferase,aspartate aminotransferase and blood sodium between the two groups(P>0.05).The multivariate Logistic regression analysis showed that abnormal lipid metabolism,stress hyperglycemia and hyperhcy were the risk factors of malignant ventricular arrhythmia occurred in patients with STEMI(P<0.05).Conclusion Malignant ventricular arrhythmia in patients with STEMI was related to abnormal lipid metabolism,stress hyperglycemia and hyperhcy.