超早产儿出生窒息的危险因素分析

目的 探讨超早产儿发生出生窒息的危险因素.方法 选取2017年1月至2020年6月,解放军总医院第七医学中心儿科医学部超早产重症监护病房收治的超早产儿为研究对象,纳入窒息组184例,对照组153例.回顾性收集超早产儿及其母亲的临床资料,分析超早产儿发生出生窒息的危险因素.统计学方法采用t检验、χ2检验、单自变量和多自变...

Analysis of risk factors of birth asphyxia in extremely premature infants

Objective To explore the risk factors of birth asphyxia in extremely premature infants.Methods From January 2017 to June 2020,extremely premature infants admitted to the Intensive Care Unit of Extremely Premature Infants,Senior Department of Pediatrics,the Seventh Medical Center of PLA General Hospital were selected as the study subjects,including 184 cases in the asphyxia group and 153 cases in the control group.The clinical data of extremely premature infants and their mothers were retrospectively collected to analyze the risk factors of birth asphyxia in extremely premature infants.Statistical methods of t test,χ² test,univariate and multivariate binary Logistic analysis were used.Results The incidence of hypertension during pregnancy in asphyxia group was higher than that in control group19.0%(35/184)vs 9.2%(14/153),χ²=6.551,P=0.010],and the incidence of infection during pregnancy was lower than that in control group10.9%(20/184)vs 19.0%(29/153),χ²=4.394,P=0.036].The gestational age and birth weight of extremely premature infants in asphyxia group were lower than those in control groupgestational age(26.4±1.2)vs(26.9±0.9)weeks,t=–3.88,P<0.001;birth weight(936±194)vs(999±177)g,t=–3.058,P=0.002],while the proportion of abnormal umbilical cord was higher than that of the control group18.5%(34/184)vs 10.5%(16/153),χ²=4.253,P=0.039].With the occurrence of neonatal asphyxia as the dependent variable,factors with P<0.1 in univariate analysis were included into the model,and further univariate and multivariate binary Logistic analysis was conducted.In univariate regression analysis,gestational age,birth weight,abnormal umbilical cord,hypertensive diseases during pregnancy and infection during pregnancy were correlated with asphyxia of extremely premature infants(OR values were 0.675,0.998,1.941,2.332 and 0.521,respectively,all P<0.05).In multivariate regression analysis,gestational age was negatively correlated with asphyxia(OR=0.719,P=0.004),and umbilical cord abnormality was positively correlated with asphyxia(OR=2.172,P=0.024).Conclusion The risk factors of birth asphyxia in extremely premature infants are gestational age and abnormal umbilical cord.Early prevention and treatment of complications during pregnancy is of great significance to reduce the occurrence of premature delivery and birth asphyxia.