疏血通注射液对下肢动脉硬化闭塞症患者血流动力学的影响

目的 探讨疏血通注射液在下肢动脉硬化闭塞症患者中的临床效果及对血流动力学的影响。方法 选择2018年6月—2020年1月下肢动脉硬化闭塞症患者118例作为对象，随机数字表法分为两组，各59例。对照组采用前列地尔注射液治疗，观察组采用疏血通注射液治疗，治疗后4周对患者效果进行评估并完成6个月随访，比较两组肢体循环评分、肱踝指数（ankle-brachial index,ABI）、血流动力学水平、脂联素水平、总动脉血流量、不良反应及终点事件。结果 观察组治疗后4周肢体循环、皮肤温度、疼痛和ABI评分均高于对照组，差异有统计学意义（P <0.05）；观察组治疗后4周全血高切黏度、血浆黏度、红细胞沉降率、红细胞电泳及纤维蛋白原水平均低于对照组，差异有统计学意义（P<0.05）；治疗后4周两组脂联素水平、总动脉血流量水平均有所升高，观察组脂联素水平、总动脉血流量水平均高于对照组，差异有统计学意义（P <0.05）；两组用药期间肝肾异常、恶心呕吐、血压波动发生率差异无统计学意义（P> 0.05）；观察组治疗随访期间进入Ⅳ期、截肢发生率低于对照组，差异有统计学意义（P <...

Effect of Shuxuetong Injection in Patients With Lower Extremity Arteriosclerosis Obliterans on Hemodynamics

Objective To investigate the effect of Shuxuetong injection in patients with lower extremity arteriosclerosis obliterans on hemodynamics.Methods A total of 118 patients with lower extremity arteriosclerosis obliterans from June 2018 to January 2020 were selected as the subjects and randomly divided into two groups with 59 cases in each group by random number method.The control group was treated with alprostadil injection,and the observation group was treated with Shuxuetong injection.After 4 weeks of treatment,the effect of the patients was evaluated and the follow-up was completed for 6 months.Compared limb circulation score,ankle-brachial index(ABI),hemodynamic level,adiponectin level,total arterial blood flow,adverse reactions and end points of two groups.Results The scores of limb circulation,skin temperature,pain and ABI score in the observation group were higher than those in the control group at 4 weeks after treatment,and the difference was statistically significant(P<0.05).Whole blood high shear viscosity,plasma viscosity,erythrocyte sedimentation rate,erythrocyte electrophoresis and fibrinogen in the observation group at 4 weeks after treatment were lower than those in the control group,and the difference was statistically significant(P<0.05).Four weeks after treatment,the levels of adiponectin and total arterial blood flow in the two groups were increased,and the levels of adiponectin and total arterial blood flow in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of liver and kidney abnormalities,nausea and vomiting,and blood pressure fluctuation between the two groups during treatment(P>0.05).The incidence of stageⅣand amputation in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Shuxuetong injection in patients with lower extremity arterosclerosis occlusive disease can improve limb circulation score and ankle-brachial index,improve hemodynamic level,effectively increase adiponectin level and carotid blood flow,without increasing the incidence of adverse reactions,and reduce the incidence of endpoint events,which is worthy of popularization and application.