不同剂量右美托咪定用于老年高血压患者全麻诱导期对血流动力学及认知功能的影响

目的 探讨不同剂量右美托咪定用于老年高血压患者全麻诱导期对血流动力学及认知功能的影响.方法 选取2020年1月至2021年1月我院收治的300例老年高血压患者为研究对象,根据随机数字表法将其分为A组和B组,各150例.A组予以右美托咪定0.2μg/kg,B组予以右美托咪定0.6μg/kg.比较两组的血流动力学指标、应激...

Effects of different doses of dexmedetomidine on hemodynamics and cognitive function in elderly patients with hypertension during general anesthesia induction

Objective To explore the effects of different doses of dexmedetomidine on hemodynamics and cognitive function in elderly patients with hypertension during general anesthesia induction.Methods A total of 300 elderly patients with hypertension treated in our hospital from January 2020 to January 2021 were selected as the research objects.According to random number table method,the patients were divided into group A and group B,with 150 cases in each group.The group A was given dexmedetomidine with 0.2μg/kg,and the group B was given dexmedetomidine with 0.6μg/kg.The hemodynamics indexes,stress response indexes,cognitive function score,postoperative awakening quality and accurrence of adverse reactions were compared between the two groups.Results At T₁,T₂,T₃ and T₄,DBP,SBP,MAP and HR in the two groups were significantly lower than those at T0(P<0.05).At T₁,T₂,T₃ and T₄,the levels of cortisol,epinephrine and norepinephrine in the two groups were significantly higher than those at T0(P<0.05).At 1,3 and 5 d after operation,the MMSE score in the group A was higher than that in the group B(P<0.05).The recovery time,extubation time and consciousness recovery time of the group A were shorter than those of the group B(P<0.05).The incidences of bradycardia and hypertension in the group A were lower than those in the group B,and the differences were statistically significant(P<0.05).Conclusion Clinical application of 0.2μg/kg or 0.6μg/kg of dexmedetomidine in elderly patients with hypertension during general anesthesia induction can maintain hemodynamics stability and reduce stress response,but 0.2μg/kg of dexmedetomidine is more beneficial to improve the cognitive function of patients after operation and the awakening quality,and reduce the risk of adverse reactions.