大剂量盐酸氨溴索联合无创正压通气对慢性阻塞性肺疾病患者血氧状态及氧化应激指标的影响

目的 探讨大剂量盐酸氨溴索联合无创正压通气治疗慢性阻塞性肺疾病的临床效果.方法 选取2017年6月至2020年12月收治的70例慢性阻塞性肺疾病患者作为研究对象,根据随机数字表法将其分为对照组(35例)和观察组(35例).对照组给予常规剂量盐酸氨溴索联合无创正压通气治疗,观察组应用大剂量盐酸氨溴索联合无创正压通气治疗....

Effects of high-dose ambroxol hydrochloride combined with noninvasive positive pressure ventilation on blood oxygen status and oxidative stress indexes in patients with chronic obstructive pulmonary disease

Objective To explore the clinical effect of high-dose ambroxol hydrochloride combined with noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease.Methods Seventy patients with chronic obstructive pulmonary disease treated from June 2017 to December 2020 were selected as the research objects.According to the random number table method,the patients were divided into control group(35 cases)and observation group(35 cases).The control group was treated with conventional dose ambroxol hydrochloride combined with noninvasive positive pressure ventilation,and the observation group was treated with high-dose ambroxol hydrochloride combined with noninvasive positive pressure ventilation.The therapeutic effects of the two groups were compared.Results After treatment,PO₂and pH in the observation group were higher than those in the control group,and PCO₂was lower than that in the control group(P<0.05).After treatment,the levels of SOD and GSH-Px in the observation group were higher than those in the control group,and the level of MDA was lower than that in the control group(P<0.05).After treatment,the PEEPi and airway resistance in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CRP,TNF-α,TGF-βand SFRP1 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion High-dose ambroxol hydrochloride combined with noninvasive positive pressure ventilation in the clinical treatment of chronic obstructive pulmonary disease can help to improve the effect of patients'blood oxygen status,reduce oxidative stress response and improve respiratory function,and will not increase adverse reactions.It has high safety and is worthy of popularization and application.