噻托溴铵奥达特罗吸入喷雾剂治疗慢性阻塞性肺疾病的临床效果

目的 探讨噻托溴铵奥达特罗吸入喷雾剂治疗慢性阻塞性肺疾病(COPD)的临床效果.方法 选取2019年10月至2020年9月本院58例COPD患者作为研究对象,根据随机数字表法将其分为对照组和观察组,各29例.在常规治疗的基础上,对照组给予噻托溴铵治疗,观察组给予噻托溴铵奥达特罗吸入喷雾剂治疗.比较两组的血清炎症因子水平...

Clinical effect of tiotropium bromide and olodaterol hydrochloride inhalation spray in the treatment of chronic obstructive pulmonary disease

Objective To explore the clinical effect of tiotropium bromide and olodaterol hydrochloride inhalation spray in the treatment of chronic obstructive pulmonary disease(COPD).Methods A total of 58 patients with COPD in our hospital from October 2019 to September 2020 were selected as the research objects.The patients were divided into control group and observation group according to random number table method,with 29 cases in each group.On the basis of routine treatment,the control group was treated with tiotropium bromide,and the observation group was treated with tiotropium bromide and olodaterol hydrochloride inhalation spray.The serum inflammatory factors levels,BODE index,pulmonary function indexes,clinical efficacy,occurrence of adverse reactions and quality of life were compared between the two groups.Results After treatment,the hs-CRP,IL-6 and TNF-α levels in the observation were lower than those in the control group(P<0.05).After treatment,the BMI,FEV1%,mMRC,6 MWD and BODE index score in the observation group were better than those in the control group(P<0.05).After treatment,FEV1,FVC and PEF in the observation group were higher than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P <0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,the SGRQ score of the observation group was lower than that of the control group(P <0.05).Conclusion Tiotropium bromide and olodaterol hydrochloride inhalation spray in the treatment of patients with COPD has a significant effect.It can reduce the serum inflammatory factors levels,ameliorate BODE index and pulmonary function,and improve the quality of life.