高通量血液透析联合在线血液透析对维持性血液透析患者钙磷代谢及微炎症状态的影响

目的 探讨高通量血液透析联合在线血液透析对维持性血液透析患者钙磷代谢及微炎症状态的影响。方法 选择2018年11月至2020年12月我院进行血液透析患者80例作为研究对象，依据治疗方法的不同将其分为对照组和观察组，各40例。对照组采取高通量血液透析治疗，观察组采取高通量血液透析联合在线血液透析治疗。比较两组的钙磷代谢指标、PTH、Cr、ALB及炎症因子水平。结果 治疗后，两组的血清钙水平较治疗前升高，血清磷水平较治疗前降低，且观察组优于对照组，差异具有统计学意义（P<0.05）。治疗后，两组的PTH、Cr水平较治疗前降低，ALB水平较治疗前升高，且观察组优于对照组，差异具有统计学意义（P<0.05）。治疗后，两组的CRP、TNF-α和IL-6水平均较治疗前明显降低，且观察组低于对照组，差异具有统计学意义（P<0.05）。结论 维持性血液透析患者采用高通量血液透析联合在线血液透析治疗，可有效改善钙磷代谢，减轻微炎症状态。

Effects of high-flux hemodialysis combined with on-line hemodialysis on calcium and phosphorus metabolism and micro-inflammation status in maintenance hemodialysis patients

Objective To investigate the effects of high-flux hemodialysis combined with on-line hemodialysis on calcium and phosphorus metabolism and micro-inflammation status in maintenance hemodialysis patients.Methods Eighty hemodialysis patients in our hospital from November 2018 to December 2020 were selected as the research objects and divided into control group and observation group according to different treatment methods,with 40 cases in each group.The control group was treated with high-flux hemodialysis,and the observation group was treated with high-flux hemodialysis combined with on-line hemodialysis.The calcium and phosphorus metabolism indexes,PTH,Cr,ALB and inflammatory factors levels were compared between the two groups.Results After treatment,the serum calcium level of the two groups was higher than that before treatment,the serum phosphorus level was lower than that before treatment,those of the observation group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of PTH and Cr in the two groups were lower than those before treatment,the level of ALB was higher than that before treatment,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CRP,TNF-αand IL-6 in the two groups were significantly lower than those before treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).Conclusion High-flux hemodialysis combined with on-line hemodialysis can effectively improve calcium and phosphorus metabolism and reduce micro-inflammation status in maintenance hemodialysis patients.