| CD55对子宫内膜的影响及可能机制 |
| |
| 引用本文： | 唐芷菁,张炜. CD55对子宫内膜的影响及可能机制[J]. 中华生殖与避孕杂志, 2022, 0(1): 104-108 |
| |
| 作者姓名： | 唐芷菁 张炜 |
| |
| 作者单位： | 复旦大学附属妇产科医院生殖内分泌科 |
| |
| 基金项目： | 国家自然科学基金(81771587)。 |
| |
| 摘 要： | 妊娠的建立依赖于子宫内膜正常的功能状态，CD55在分泌期子宫内膜表达逐渐上调并在分泌中期达到峰值，而CD55的异常表达与反复流产和着床失败、子宫内膜异位症、内膜癌等多种子宫内膜相关疾病有关。除了作为补体调节蛋白抑制补体介导的细胞杀伤作用以外，CD55在子宫内膜中还参与调节细胞周期，促进细胞增殖抑制凋亡，促进细胞侵袭迁移...
|
| 关 键 词： | CD55 子宫内膜 妊娠 生物学行为 |
Function and potential mechanism of CD55 in endometrium |
| |
| Tang Zhijing,Zhang Wei. Function and potential mechanism of CD55 in endometrium[J]. Chinese Journal of Reproduction and Contraception, 2022, 0(1): 104-108 |
| |
| Authors: | Tang Zhijing Zhang Wei |
| |
| Affiliation: | (Department of Reproductive Endocrinology,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China) |
| |
| Abstract: | The establishment of pregnancy depends on the normal function of endometrium.CD55 is up-regulated in the secretory endometrium and reaches the peak during the window of implantation,while abnormal expression of CD55 is associated with recurrent abortion,repeated implantation failure,endometriosis,endometrial cancer and other endometria-related diseases.Besides inhibiting the complement-dependent cytotoxicity as a complement regulatory protein,CD55 in endometrium also plays a role in regulating cell cycle,promoting cell proliferation,inhibiting apoptosis,and promoting cell invasion,migration and adhesion.CD55 can also bind its ligand CD97 as inhibitory signals of T cells and natural killer(NK)cells and participate in promoting cell invasion and migration in non-immune cells.This review summarizes the role of CD55 in endometrium and its potential regulatory mechanism,providing more evidence for exploring the function of CD55 in endometrial receptivity establishment and embryo implantation. |
| |
| Keywords: | CD55 Endometrium Gestation Biological behavior |
| 本文献已被 维普 等数据库收录！ |
|
