西格列汀联合津力达颗粒治疗老年2型糖尿病疗效及安全性

目的 探讨西格列汀联合津力达颗粒治疗老年2型糖尿病的疗效和安全性。方法 选取我院2019年5月至2020年1月期间收治的90例老年2型糖尿病患者为研究对象，按随机数字表法分为对照组和观察组，各45例。对照组患者给予口服西格列汀片治疗，100 mg/次，1次/d,观察组患者在对照组治疗方案的基础上联用津力达颗粒治疗，9g/次，3次/d。统计两组患者治疗效果、血糖指标和胰岛功能指标变化以及不良反应发生情况。结果 观察组临床总有效率为93.3%,显著高于对照组；两组患者血糖指标和胰岛功能指标均显著改善，但观察组水平显著优于对照组；观察组总不良反应发生率为8.9%,显著低于对照组，差异均具有统计学意义(P<0.05)。结论 西格列汀联合津力达颗粒治疗老年2型糖尿病，作用机制互补，疗效确切，安全性高，值得临床推广。

Efficacy and safety of Sitagliptin combined with Jinlida granules in the treatment of elderly type 2 diabetes

Objective To explore the efficacy and safety of sitagliptin combined with Jinlida granules in the treatment of type 2 diabetes in the elderly.Methods A total of 90 elderly patients with type 2 diabetes who were admitted to our hospital from May 2019 to January 2020 were selected as the research subjects.They were divided into control group and observation group,with 45 cases in each group according to the digital table method.Patients in control group were treated with oral sitagliptin tablets and patients in the observation group were treated with Jinlida granules on the basis of the control group.The treatment effect,blood glucose index,islet function index,and adverse reactions of the two groups of patients were counted.Results After treatment,the total clinical effective rate of the observation group was 93.3%,which was significantly higher than the control group.The blood glucose and islet function indexes of the two groups of patients were significantly improved,but the level of the observation group was significantly better than that of the control group.The reaction rate was 8.9%,which was significantly lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Sitagliptin combined with Jinlida granules in the treatment of elderly type 2 diabetes,the action mechanism of the two drugs is complementary,the curative effect is accurate,and the safety is high.It is worthy of clinical promotion.