干燥综合征伴周围神经病变的临床电生理与病理特点

目的 探究干燥综合征伴周围神经病变的临床电生理与病理特点.方法 以2018年1月至2021年1月收治的50例干燥综合征伴周围神经病变患者为试验组,同时以50例干燥综合征不伴周围神经病变患者为对照组.分析试验组临床电生理以及病理特点,比较两组患者临床表现的差异性.结果 试验组感觉神经传导异常患者中,10.00％为尺神经受...

Clinical electrophysiology and pathological character of Sjogren's syndrome complicated with peripheral neuropathy

Objective To investigate the clinical electrophysiology and pathological character of Sjogren's syndrome complicated with peripheral neuropathy.Methods A total of 50 patients with Sjogren's syndrome complicated with peripheral neuropathy treated from January 2018 to January 2021 were selected as experimental group,and 50 patients with Sjogren's syndrome without peripheral neuropathy were selected as control group.The clinical electrophysiology and pathological character of the experimental group were analyzed,and the differences of clinical manifestations between the two groups were compared.Results Among the patients with abnormal sensory nerve conduction in the experimental group,10.00%were ulnar nerve involvement,20.00%were median nerve involvement,and 70.00%were peroneal nerve involvement;among the patients with abnormal motor nerve conduction,63.64%were peroneal nerve involvement and 36.36%were ulnar nerve involvement;12.00%had abnormal complex muscle action potential amplitude or/and sensory potential amplitude,6.00%had no sensory nerve conduction action potential of left sural nerve,4.00%had reduced complex muscle action potential amplitude of left peroneal nerve motor conduction;needle electromyography showed that 32.00%were accompanied by neurogenic damage,24.00%were abductor pollicis brevis,22.00%were anterior cervical muscle and 6.00%were quadriceps femoris muscle.Demyelination and release of myelin sheath were found in 58.00%;fibroocclusive vasculitis of interfascicular vessels were found in 38.00%;skin biopsy showed non-specific perivasculitis in 18.00%.The labial gland examination showed lymphocytic infiltration in 34.00%.The incidences of limb numbness and joint swelling and pain in the experimental group were higher than those in the control group(P<0.05).Conclusion Patients with Sjogren's syndrome complicated with peripheral neuropathy have electrophysiological abnormalities of sensory nerve and motor nerve.Pathological examination showed vasculitis and decreased myelinated nerve fibers.And there will be limb numbness,joint swelling and pain and other symptoms.