氟马西尼治疗急性苯二氮(艹卓)类药物中毒的疗效观察

目的 探讨苯二氮[艹卓]受体拮抗剂——氟马西尼治疗昏迷的临床价值。方法 随机将61例急性苯二氮[艹卓]类药物（BZDs）中毒患者分为氟马西尼治疗组和对照组、其中对照组30例，用一般治疗和酌情加用呼吸兴奋剂、纳洛酮；治疗组31例，在对照组治疗基础上加用氟马西尼静脉注射。采用Glasgow—Pattoburgh评分量表和观察者对患者机敏力／镇静程度评判量表（OAA／S）进行疗效判断。结果31例BZDs中毒患者经氟马西尼治疗后，5、15、30、60、120和180min Glasgow—Pattoburgh得分较治疗前分别增加了：2．1、5．2、7．3、8．1、8．4、7．3，与对照组各时段比较Glasgow—Pattoburgh得分分别增加了：1．8、4．4、6．4、6．7、6．7、5．4，差异均有统计学意义（P〈0．01）．以OAA／S比较两组疗效．治疗组治疗后平均得分增加2．0，与对照组比较差异也有统计学意义（P〈0．01）。结论 氟马西尼治疗急性BZDs中毒有明显的症状逆转作用，且无严重不良反应。

To observe the therapeutic effect of flumazenit on acute benzodiazepine poisoning

Objective To study the therapentic effect of flumazenit on acute benzodiazepine poisoning. Methods Sixty-one patients with unconsciousness due to acute benzodiazepine poisoning were randomly divided into two groups:flumazenit group(n = 31) and conventional-medicine group(n= 30). A modified Glasgow-Pattoburgh and observer's assessment of alertness/sedation scale(OAA/S) were used in assessment of the mental status. Results Glasgow-Pattoburgh were increased by 2.1,5.2,7.3,8.1,8.4 and 7.3 at 5min,15min,30min,60min,120min and 180min after intravenous flumazenil treatment compared with baseline value(P<0.01),and by 1.8,4.4,6.4,6.7, 6.7 and 5.4 in comparison with convetional-medicine group(P<0.01). OAA/S increased by 2.0(P<0.01) compared with conventional-medicine group. Conclusion Flumazenil can markedly alleviate benzodiazepine-induced unconsciousness without serious side-effect.