c-Met蛋白在乳腺癌中的表达及临床病理意义

目的 探讨乳腺癌中c-Met蛋白的表达情况及其临床病理意义.方法 收集我院病理科2011年10月～2012年10月150例乳腺癌石蜡标本,采用免疫组织化学方法对其c-Met蛋白的表达情况进行检测,以统计分析软件SPSS17.0对其与年龄、肿瘤大小、病理分级、淋巴结是否转移、TNM分期之间的关系进行评价.结果 c-Met阳性表达及阴性表达的例数为62（41.33%）、88（58.67%）.c-Met在正常乳腺组织中为阴性表达.淋巴结转移的患者的阳性表达率明显高于无淋巴结转移组;TNM分期中,Ⅲ~Ⅳ组中的阳性表达率明显高于Ⅰ~Ⅱ组,差异有统计学意义（P ＜ 0.05）.多因素分析结果表明,乳腺癌发生发展中c-Met不是其独立的预后因子.结论乳腺癌中的c-Met蛋白的表达差异具有显著性,淋巴结出现转移后及患者具有较高的TNM分期则其表达出现增强,提示c-Met在乳腺癌的发生及侵袭、转移过程中起着非常重要的作用.

Analysis the expression and the clinicopathological significance of c-Met protein in breast cancer

Objective To explore the expression and the clinicopathological significance of c-Met protein in breast cancer. Methods A total of 150 cases with paraffin-embedded specimens of breast cancer were selected from October 2011 to October 2012 period in our hospital, we detected the expression of the c-Met protein with immunohistochem- ical methods, and analyzed their age, tumor size, histological grade, lymph node metastasis, the relationship between the TNM staging with statistical analysis software SPSS17.0. Results The expression of c-Met-positive were 62 （41.33%）cases, and the expression of c-Met-negative were 88 （58.67%）cases. C-Met was negative expression in normal breast tissue. Lymph node metastasis in patients with positive expression rate was significantly higher than that without lymph node metastasis, and TNM staging, the positive expression rate was significantly higher than the group m-IV, I - lI group, the difference was statistically significant （P 〈 0.05）. Multivariate analysis showed that breast cancer developing c-Met was not an independent prognostic factor. Conclusion The differential expression of the c- Met protein in breast cancer has significantly enhanced its expression, suggesting that c-Met in the incidence of breast cancer and invasion, metastasis, lymph nodes appear after the transfer, and patients with a higher TNM stage onwardsa very important role.