Global and regional left ventricular function: a comparison between gated SPECT, 2D echocardiography and multi-slice computed tomography |
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Authors: | Maureen M Henneman Jeroen J Bax Joanne D Schuijf J Wouter Jukema Eduard R Holman Marcel P M Stokkel Hildo J Lamb Albert de Roos Ernst E van der Wall |
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Institution: | (1) Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;(2) The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands;(3) Department of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands;(4) Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands |
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Abstract: | Purpose Global and regional left ventricular (LV) function are important indicators of the cardiac status in patients with coronary
artery disease (CAD). Therapy and prognosis are to a large extent dependent on LV function. Multi-slice computed tomography
(MSCT) has already earned its place as an imaging modality for non-invasive assessment of the coronary arteries, but since
retrospective gating to the patient’s ECG is performed, information on LV function can be derived.
Methods In 49 patients with known or suspected CAD, coronary angiography with MSCT imaging was performed, in addition to gated SPECT
and 2D echocardiography. LV end-diastolic and LV end-systolic volumes and LV ejection fraction were analysed with dedicated
software (CMR Analytical Software System, Medis, Leiden, The Netherlands for MSCT; gated SPECT by QGS, Cedars-Sinai Medical
Center, Los Angeles, CA, USA), and by the biplane Simpson’s rule for 2D echocardiography. Regional wall motion was evaluated
according to a 17-segment model and a three-point score system.
Results Correlations were fairly good between gated SPECT and MSCT (LVEDV: r=0.65; LVESV: r=0.63; LVEF: r=0.60), and excellent between 2D echocardiography and MSCT (LVEDV: r=0.92; LVESV: r=0.93; LVEF: r=0.80). Agreement for regional wall motion was 95% (κ=0.66) between gated SPECT and MSCT, and 96% (κ=0.73) between 2D echocardiography
and MSCT.
Conclusion Global and regional LV function and LV volumes can be adequately assessed with MSCT. Correlations with 2D echocardiography
are stronger than with gated SPECT. |
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Keywords: | CT Gated SPECT Echocardiography Global left ventricular function Regional left ventricular function |
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