| HCV感染者外周血T淋巴细胞亚群的变化 |
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| 引用本文： | 刘毓刚,王天然,李国良.HCV感染者外周血T淋巴细胞亚群的变化[J].四川医学,2010,31(2):241-242. |
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| 作者姓名： | 刘毓刚 王天然 李国良 |
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| 作者单位： | 成都军区总医院检验科,四川,成都,610083 |
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| 摘 要： | 目的研究HCV感染者在病程各阶段外周血T淋巴细胞亚群的变化。方法流式细胞仪检测丙型肝炎患者CD4^＋、CD8^＋T淋巴细胞，并将其分为急性期组，慢性期组检测CD4^＋CD25^＋、CD4^＋CD28^-T淋巴细胞。结果丙型肝炎患者CD4^＋T细胞降低，CD8^＋T细胞升高，CD4^＋／CD8^＋降低，与对照组差异有统计学意义（P〈0．05）。急性期组CD4^＋CD25^＋与正常对照组差异无统计学意义（P〉0．05），但CD4^＋／CD28^-T细胞显著高于对照组（P〈0．05）、慢性期组CD4^＋CD25^＋T细胞显著增高，而CD4^＋CD28^-T细胞显著低于对照组（P〈0．05）。结论丙型肝炎患者CD4^＋／CD8^＋明显降低，机体免疫状态紊乱，在各病程阶段CD4^＋CD25^＋、CD4^＋CD28^-T细胞比率明显变化，说明此淋巴细胞亚群与丙型肝炎的发病及发展有密切关系。
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| 关 键 词： | 丙型肝炎 CD4^＋／CD8^＋ CD4^＋CD25^＋T细胞 CD4^＋CD28^-T细胞 |
Changes of T cell subsets of peripheral blood in patients with HCV infection |
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| LIU Yu-gang,WANG Tian-ran,LI Guo-liang.Chengdu Military General Hospital,Chengdu,Sichuan ,China.Changes of T cell subsets of peripheral blood in patients with HCV infection[J].Sichuan Medical Journal,2010,31(2):241-242. |
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| Authors: | LIU Yu-gang WANG Tian-ran LI Guo-liangChengdu Military General Hospital Chengdu Sichuan China |
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| Institution: | LIU Yu-gang,WANG Tian-ran,LI Guo-liang.Chengdu Military General Hospital,Chengdu,Sichuan 610083,China |
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| Abstract: | Objective The changes of peripheral blood T lymphocyte subsets in patients with HCV infection in different courses of disease were studied.Methods Flow cytometry was used to determine the number of CD+4,CD+8,CD+4CD+25and CD+4CD-28T lymphocyte in patients with HCV infection;and results were analyzed statistically.Results Significantly lower percentage of CD+4T lymphocyte,and higher of CD+8,with CD+4/CD+8 ratio in HCV patients than those in normal control people(P<0.05),were demonstrated in the results.I t wa... |
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| Keywords: | CD4+/CD8+ CD4+CD25+ |
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