抑癌基因PTEN、p27与子宫内膜异位症发病的关系

目的:探讨抑癌基因PTEN、p27在子宫内膜异位症(EMs)发生、发展中的作用。方法:采用免疫组化SP法检测32例EMs患者(EMs组)在位及异位子宫内膜PTEN和p27的表达,并与20例正常内膜对照组在位内膜进行比较。结果:PTEN、p27在EMs组异位和在位内膜的表达无显著差异(P>0.05),但二者均低于对照组水平(P<0.05);PTEN、p27在EMsⅠ-Ⅱ期的表达显著高于Ⅲ-Ⅳ期(P<0.05),并与EMsr-AFS分期呈负相关(P<0.05)。各组内膜PTEN和p27的表达均呈正相关(P<0.05)。对照组PTEN、p27分泌期的表达均高于增生期(P<0.05),而EMs组在位内膜的表达均无周期性改变(P>0.05),但其分泌期的表达显著低于对照组同期水平(P<0.05)。结论:抑癌基因PTEN、p27在EMs在位和异位内膜的低表达及二者的协同作用,可能与EMs的发生发展有密切关系。

Correlation between Inhibitor Gene PTEN and p27 in the Pathogenisis of Endometriosis

Objective: To explore the effective of tumor suppression gene PTEN and p27 in the pathogenesis of endometriosis(EMs). Methods: Immunohistochemical Streptavidin-peroxidase (SP) methods was used to examine the expression of PTEN and p27 in eutopic and ectopic endometrium from 32 cases with EMs which compared with 20 cases with normal endometrium (control group). Results: The expression of the PTEN and p27 had no significant difference between ectopic endometrium and eutopic endometrium of EMs (P>0.05), but they were lower than that of the control (P<0.05). The expression of PTEN and p27 in endometriosis stageⅠ-Ⅱ was significant higher than the stage Ⅲ-Ⅳ (P<0.05). There had a negative spearman correlation between the expression of PTEN and p27 and the r-AFS clinical staging of EMs (P<0.05). There was a positive spearman correlation between the expression of PTEN and p27 in each group (P<0.05). The expression of p27 and PTEN had no significant difference between the proliferative and secretive phase in EMs (P>0.05), but in the control they were all higher in secretive than proliferative phase (P<0.05), the expression of p27 and PTEN in secrective phase of endometriosis was lower than the same phase of the control (P<0.05). Conclusion: The lower expression of PTEN and p27 in eutopic and ectopic endometrium of EMs and the cooperation of PTEN and p27 may play a crucial role for the pathogenesis and the progress of EMs.