| 利用彗星分析法探讨氯乙烯聚合工人DNA损害 |
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| 引用本文： | 熊文辉,杨倬.利用彗星分析法探讨氯乙烯聚合工人DNA损害[J].现代预防医学,2006,33(7):1105-1106,1108. |
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| 作者姓名： | 熊文辉 杨倬 |
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| 作者单位： | 1. 深圳市龙岗区疾病预防控制中心,深圳,518172
2. 深圳市龙岗区卫生监督所 |
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| 摘 要： | 目的：探讨低浓度氯乙烯暴露（〈5ppm）和DNA伤害的相关性。方法：彗星分析法、Student＇s t-test和ANOVA检验。结果：在低浓度的氯乙烯暴露下（0．05-13．38ppm），仍然可以观察到在环境氯乙烯浓度大于1ppm的工人比小于1ppm的工人有较多的DNA单股断裂（P〈0．05）。结论：车间空气中氯乙烯的浓度即使达到法定容许浓度，仍可能对劳动者健康造成损害。
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| 关 键 词： | 聚氯乙烯 彗星分析 DNA单股断裂 |
| 文章编号： | 1003-8507（2006）07-1105-03 |
| 收稿时间： | 2006-01-13 |
| 修稿时间： | 2006-01-13 |
DETECTION OF DNA DAMAGE WITH COMET ASSAY IN POLYVINYL CHLORIDE WORKERS |
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| XIONG Wen-hui,YANG Zhuo.DETECTION OF DNA DAMAGE WITH COMET ASSAY IN POLYVINYL CHLORIDE WORKERS[J].Modern Preventive Medicine,2006,33(7):1105-1106,1108. |
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| Authors: | XIONG Wen-hui YANG Zhuo |
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| Institution: | Longgang Center for Disease Control and Prevention of Shenzhen, Shenzhen, 518172. |
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| Abstract: | Objective:To determine the dose-response relationship between the low dose exposure to Vinyl chloride monomer(VCM)and DNA damage remains unclear.Methods:Comet assay,Student's t-test and ANOVA test were used to assess the relationship.Results:The low dose exposure to VCM(0.05-13.38 ppm)of >1 ppm can cause more DNA single-strand breaks than the exposure to that of<1 ppm.Conclusion:The results revealed that VCM may cause DNA damage at air levels below current TWA-PEL(10 ppm). |
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| Keywords: | Polyvinyl chloride comet assay DNA single-strand breaks |
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