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The Familial Intracranial Aneurysm (FIA) study protocol |
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| Authors: | Joseph P Broderick Laura R Sauerbeck Tatiana Foroud John Huston Nathan Pankratz Irene Meissner Robert D Brown |
| Affiliation: | (1) Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, 45267-0525 Cincinnati, OH, USA;(2) Medical & Molecular Genetics, Indiana University, 975 West Walnut St., IB 130, 46202-5251 Indianapolis, IN, USA;(3) Department of Radiology, Mayo Clinic, 200 First Street SW, 55905 Rochester, MN, USA;(4) Division of Cerebrovascular Disease and Department of Neurology, Mayo Clinic, 200, First Street SW, 55905 Rochester, MN, USA |
| Abstract: | BackgroundSubarachnoid hemorrhage (SAH) due to ruptured intracranial aneurysms (IAs) occurs in about 20,000 people per year in the U.S. annually and nearly half of the affected persons are dead within the first 30 days. Survivors of ruptured IAs are often left with substantial disability. Thus, primary prevention of aneurysm formation and rupture is of paramount importance. Prior studies indicate that genetic factors are important in the formation and rupture of IAs. The long-term goal of the Familial Intracranial Aneurysm (FIA) Study is to identify genes that underlie the development and rupture of intracranial aneurysms (IA). |
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