In situ localization of NF-H neurofilament subunit mRNAs in rat brain |
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Authors: | G Roussel J M Felix A Dautigny D Pham-Dinh C Hindelang P Jollès J L Nussbaum |
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Affiliation: | Centre de Neurochimie du CNRS and U44 de l'INSERM, Strasbourg, France. |
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Abstract: | The expression of NF-H neurofilament subunit mRNAs was investigated in the rat brain at different ontogenic stages. The levels of NF-H mRNAs vary 15-fold among brain regions with the highest level in the brainstem. In situ localization studies revealed that the NF-H mRNAs are mainly concentrated in the brainstem motoneuron nuclei. By increasing the sensitivity of the hybridization method, NF-H mRNAs could also be localized in neurons present in the cortex, thalamus and hippocampus areas. Minor amounts of NF-H mRNAs were already detected at 17-day embryonic stages. |
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