高通量血液透析对甲状旁腺素的影响

目的探讨高透量血液透析（HFHD）对甲状旁腺素（PTH）的影响。方法选择30例维持性血液透析患者,先后接受血液透析（HD）和高通量血液透析两种透析方式,HD选用费森尤斯F6透析器,超率系数为5.5ml/（h.mmHg）,聚砜膜,表面积为1.3m×1.3m,HFHD选用德国费森尤斯F60透析器,超率系数为40ml/（h·mm-Hg）,聚砜膜,表面积为1.3m×1.3m。分别于单次透析前、后测定患者血清尿素氮（BUN）、肌酐（Cr）、钙（Ca）、磷（P）、甲状旁腺素（PTH）和瘦素（Leptin）水平,计算单次透析前、后溶质下降率,并对两种透析方式溶质的下降率进行比较。结果HD和HFHD治疗后血BUN、Cr的下降率差异无统计学意义（P〉0.05）。HFHD治疗后血P、PTH和Leptin的下降率明显高于HD（P〈0.05）。结论HFHD能降低血PTH浓度。

Effect of high-flux hemodialysis on parathyroid hormone

Objective To investigate the effect of high - flux hemodialysis （HFHD） on parathyroid hormone （PTH）. MethodsThirty cases of chronic hemodialysis patients received hemodialysis （HD） and high - flux hemodialysis. Fresenius F6 polysulphone dialyzer with an area of 1.3 m^2 and an uhrafiltration coefficient of 5.5ml/h · mmHg was used in the HD, while the Fresenius F60 polysulphone dialyzer with an area of 1.3 m^2 and an uhrafihration coefficient of 40ml/h · mmHg was used in the HFHD. Blood urea nitro- gen （ BUN）, creatinine （ Cr）, phosphorus （ P）, PTH and Leptin were tested pre - hemedialysis, pest - hemedialysis. Solute clearance was figured out and compared them in HD and HFHD. Results There was no significant difference between HD and HFHD in the decrease of BUN and Cr （ P 〉 0. 05 ）. But the decrease of P, PTH and Leptin were superior to that of HD （ P 〉 0. 05 ）. Conclusion HFHD can decrease PTH level.