|
|||||
|
|
Antitumor effect of212bismuth-conjugated anti-IL-2R monoclonal antibody(2E4) on a IL-2 receptor positive tumor EL4J3.4 |
|
| Authors: | Sung Hoon Kim Robert W. Kozak Kyeong-Soo Chung Byung Zun Ahn |
| Affiliation: | 1. Oriental Medical College, Taejon University, 300-716, Taejon, Korea 2. Work Miles Inc., Regulatory Affairs, Bldg 50, 4th & Parker Streets, P.O. Box 1986, 94701, Berkeley, California, USA 3. College of Pharmacy, Chungnam National University, 305-764, TaeJon, Korea |
| Abstract: | The antitumor effects of the 2E4 and anti-Tac, monoclonal antibodies directed to IL-2 receptor (IL-2R), conjugated with α-particle emitting radionuclide bismuth-212, were compared. The212Bi-2E4 demonstrated specific cytotoxicity to EL4J3.4, a IL-2R+ cell line, than to EL4J, a IL-2R− cell line in thymidine incorporation assay.212Bi-2E4 exerted the maximal antitumor effect in that % T/C in C57BL/6 mice implanted with EL4J3.4 ascitic tumor was 331% at the concentration of 50 μCi, while that of212Bi-anti-Tac was 258% at 100 μCi. |
| Keywords: | Antitumor effect IL-2 receptor-directed monoclonal antibodies 212Bi-2E4 212Bi-anti-Tac EL4J EL4J3.4 |
| 本文献已被 SpringerLink 等数据库收录！ | |