血胆红素浓度与冠状动脉疾病的关系

目的：探讨血中胆红素浓度与冠状动脉疾病（CAD）的相关性。方法：检测216例疑为CAD而进行冠状动脉造影术患者血清的系列生化指标，并与冠状动脉狭窄度进行比较。结果：随着冠状动脉狭窄度加大，三酰甘油（TG）、总胆固醇（CHOL）逐渐增高，而总胆红素（TBIL）和高密度脂蛋白胆固醇（HDL－C）逐渐下降，冠状动脉狭窄度正常组与重度组其TBIL、TG、CHOL、HDL－C、乳酸脱酶（LDH）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）差异有显著性（P＜0．05）。其中TBIL和冠状动脉狭窄度呈负相关，结论：TBIL浓度与CAD存在负相关性，可作为CAD的又一危险因素。

The relationship between the serum concentration of the total bilirubin and coronary artery disease

Objective To study the relationship between the low serum concentration of the total bilirubin(TBIL) and coronary artery disease(CAD). Methods To examine the chemical items of 216 cases of suspected CAD patients and compared with the coronary artery stenosis. Results Along with the enhancement of the coronary artery stenosis the concentration of triglycerides(TG) and total cholesterol(CHOL) rised, but the concentration of total bilirubin (TBIL) and high-density lipoprotein cholesterol(HDL-C) reduced. There are singnificant differences in positive rates TBIL, TG, CHOL, HDL-C, lactate dehydrogenase(LDH), alanine aminotransferase(ALT), aspartate aminotransferase(AST), between normal percentage group and maximum percentage group of coronary artery stenosis(P< 0.05), in which TBIL showed negative interrelationship with coronary artery stenosis.Conclusion The low conconcentration of TBIL could be regarded as a dangerous facter of CAD.