| 青羊参总甙对小鼠脑突触体中某些氨基酸含量和脑中某些有关酶活性的影响 |
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| 引用本文： | 李建一,赵天睿,南国华,周曦.青羊参总甙对小鼠脑突触体中某些氨基酸含量和脑中某些有关酶活性的影响[J].中国药理学通报,1987(3). |
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| 作者姓名： | 李建一 赵天睿 南国华 周曦 |
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| 作者单位： | 江西医学院生物化学教研室 南昌
(李建一，赵天睿，南国华)，江西医学院生物化学教研室 南昌(周曦) |
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| 摘 要： | COS青羊参的氟仿提取物,有抗惊厥作用。本文报道ip COS可升高小鼠脑突触体中GABA含量及降低Glu、Asp含量,抑制全脑GDH、谷氨酰胺酶及门冬酰胺酶活性。对突触体中Gln含量和脑中GOT、GPT和谷氨酰胺合成酶活性无明显影响。COS对上述氨基酸含量和酶活性的影响可能与其抗惊厥作用有关。
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| 关 键 词： | 青羊参总甙 γ-氨基丁酸 谷氨酸 门冬氨酸 突触体酶 脑 |
EFFECT OF TOTAL GLYCOSIDE OF CYNANCHUM OTOPHYLLUM SCHNEID ON SYNAPTOSOMAL AMINO ACID CONTENTS AND WHOLE BRAIN ENZYME ACTIVITIES IN MICE |
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| Li Jianyi,Zhao Tianrui,Nan Guohua et al.EFFECT OF TOTAL GLYCOSIDE OF CYNANCHUM OTOPHYLLUM SCHNEID ON SYNAPTOSOMAL AMINO ACID CONTENTS AND WHOLE BRAIN ENZYME ACTIVITIES IN MICE[J].Chinese Pharmacological Bulletin,1987(3). |
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| Authors: | Li Jianyi Zhao Tianrui Nan Guohua |
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| Abstract: | The total glycoside extracted from the root of cynanchum oiophy-llum schneid ( COS ) has anticonvulsant activity. Its effect on synap-tosomal amino acid contents and brain enzyme activities in mice were studied in this paper. After the ip administration of COS, the content of GABA was increased, and that of Glu and Asp decreased, in synaptosomes of both normal and TSC induced convulsant mice, while the content of Gin remained unchanged. A fall in the activities of GDH, glutaminase and asparaginase in whole brain was seen. No changes were observed in the activities of GPT, GOT and glutamine synthetase. |
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| Keywords: | Total glycoside of cynanchum otophyllum schneid( COS) GABA Glutamate Aspartate Synaptosome Enzyme Brain |
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