CEA、P16、Ki-67在原发宫颈腺癌中的表达及意义

目的：探讨癌胚抗原（CEA）、P16、Ki-67在原发宫颈腺癌中的表达及其临床病理意义。方法采用免疫组织化学染色的方法,检测原发宫颈腺癌36例,宫颈腺体上皮内肿瘤（CGIN）14例及正常宫颈组织10例中CEA、P16、Ki-67的抗体表达的情况。结果CEA、 P16、Ki-67在实验组及对照组中,差异均有统计学意义（P〈0.05）。结论CEA、P16、Ki-67,在宫颈癌的发生、发展中有着重要作用,监测三者指标有助于原发宫颈腺癌及癌前病变的诊断。

Expression and significance of CEA,P16 and Ki-67 in primary cervical adenocarcinoma

Objective To explore expression of CEA, P16 protein and Ki-67 protein in cervical adenocarcinoma.MethodsAntibody expressions of CEA, P16 and Ki-67 in cervical glandular intraepithelial neoplasia（14 cases）, normal cervical tissue（10 cases） and primary cervical adenocarcinoma（36 cases） were detected by immunohistochemical method.ResultsThe expressions of CEA, P16 and Ki-67 in experiment group and control group have statistical difference（P〈0.05）.ConclusionCEA, P16 and Ki-67 may play an important role in occurrence and development of in primary cervical adenocarcinoma. The detection of CEA, P16 and Ki-67 contributed to the diagnosis of primary cervical adenocarcinoma and precancerous lesions.