肺瘤平对S180荷瘤小鼠抑瘤作用及免疫功能的影响

目的：探讨肺瘤平对S180荷瘤小鼠的抑瘤活性及免疫调节作用。方法：SPF级ICR小鼠腋下接种S180肉瘤细胞后随机分为模型组、阳性药紫龙金组（2.60 g·kg^-1，ig）、肺瘤平高、中、低剂量组（生药量25.00，12.50，6.25 g·kg^-1，ig），另设正常对照组。连续给药10天后处死动物，检测抑瘤率、免疫器官指数、脾淋巴细胞增殖活性、腹腔巨噬细胞吞噬鸡红细胞功能、血清半数溶血值（HC₅₀）以及自然杀伤细胞（NK）活性。结果：肺瘤平对S180肉瘤的生长具有显著的抑制作用，高、中、低剂量组的抑瘤率分别为51.88%，32.33%，37.59%，对荷瘤小鼠免疫器官指数没有明显影响；可显著增加荷瘤小鼠腹腔巨噬细胞吞噬功能和NK细胞杀伤活性，提高血清半数溶血值，促进淋巴细胞增殖反应。结论：肺瘤平对S180荷瘤小鼠具有抑瘤和增强免疫功能作用，且效果优于紫龙金片。

Antitumor and Immunoregulation Effects of Feiliuping on Mice of S180 Cells-derived Tumor

Objective: To explore the anti-tumor and immunoregulation effects of Feiliuping on S180 tumor-bearing mice. Method: The ICR mice inoculated subcutaneously with S180 cells were randomly divided into five groups:the negative control group, the positive control group (Zilongjin, 2.60 g·kg^-1, ig), high-, moderate-, and low-dose of Feiliuping groups (25.00, 12.50, 6.25 g·kg^-1, ig). Normal mice without S180 were designated as normal group. After corresponding treatments for 10 days, the tumor inhibitory rate, index of thymus and spleen, rate of peritoneal macrophage phagocytizing chicken red blood cell, level of serum hemolysin, spleen lymphocyte transformation, and NK cell killing activity were tested. Result: Feiliuping could obviously inhibit the growth of S180 sarcoma, the tumor inhibitory rates of high-, moderate-, and low-dose groups were 51.88%, 32.33%, 37.59%, respectively, however, the indexes of thymus and spleen of mice were not changed. Feiliuping significantly improved the killing activity of peritoneal macrophages and NK cells, increased the level of serum hemolysin, promoted lymphocyte transformation on mice of S180 cells-derived tumor. Conclusion: Feiliuping can inhibit the growth of S180 implant tumor and enhance the immune function of the tumor-bearing mice, the tumor growth inhibition and immune capability enhancement of Feiliuping are more effective than Zilongjin.