加味四逆散对功能性消化不良伴抑郁状态的干预作用

目的： 观察加味四逆散对功能性消化不良伴抑郁状态的临床疗效，并从胃排空试验、胃动素（MOT）、促胃液素（GAS）等方面揭示其作用机制。 方法： 将96例病例随机分为治疗组与对照组各48例，对照组给予马来酸多潘立酮片及氟哌噻吨美利曲辛片，治疗组给予加味四逆散治疗，30 d为1疗程。治疗前后检测胃动素及促胃液素，并做胃排空试验。疗程结束后评价总体疗效。 结果： ①治疗组总有效率为93.75%，对照组总有效率为77.08%（P < 0.05）；②治疗组在胃动素、促胃液素及胃排空试验方面明显优于对照组（P < 0.05）；③汉密顿抑郁量表（HAMD） 积分改善，治疗组优于对照组（P < 0.05）。 结论： 加味四逆散对功能性消化不良伴抑郁状态临床疗效确切，能够显著改善患者的临床症状，提高其生活质量。

Clinical Study on Intervening Effects on Functional Dyspepsia Plus Depression Treated with Jiawei Sinisan

Objective: To study the intervening effects on functional dyspepsia plus depression treated with Jiawei Sinisan, and the gastric emptying, motilin and gastrin were studied to demonstrate mechanism. Method: Ninety-six functional dyspepsia patients were randomly distributed into two groups, the control group treated with domperidone and St. John's wort extract, therapy group treated with taking orally Jiawei Sinisan, both course of treatment were 30 days, gastric emptying, motilin and Gastrin were studied before and after intervention,then general effect was evaluated. Result: The total effective rate was 93.75% in the therapy group whereas 77.08% in the control group, differences were significant(P < 0.05).Compared with control group,the motilin, gastrin and gastric emptying were better in therapy group, differences were significant(P < 0.05). Compared with control group, hamilton depression scale score better in the therapy group,differences were significant(P < 0.05). Conclusion: The effect of Jiawei Sinisan is certain, it could relieve clinlcal symptom of functional dyspepsia.