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苦参化学成分研究进展
引用本文:张翅,马悦,高慧敏,张启伟,王智民. 苦参化学成分研究进展[J]. 中国实验方剂学杂志, 2014, 20(4): 205-214
作者姓名:张翅  马悦  高慧敏  张启伟  王智民
作者单位:中国中医科学院中药研究所, 北京 100700;天津中医药大学, 天津 300193;中国中医科学院中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700
基金项目:国家“十二五”科技支撑计划(2011BA107B03);国家药典委员会2015年版《中国药典》任务(TS-P022);重大新药创制(2008ZX09202-009,2009ZX09308-003)
摘    要:对苦参的化学成分进行分析和总结,为其资源的综合利用与开发提供参考。苦参化学研究主要集中在根部,成分类别包括生物碱、黄酮、三萜皂苷、木脂素、酚酸和少量的苯丙素类成分,其中已分离得到了41个生物碱和108个黄酮类化合物,但是对茎、叶、花、果等非药用部位的研究较少。对苦参地上部分开展深入化学研究有利于充分利用苦参资源。

关 键 词:苦参  化学成分  生物碱  黄酮  木脂素  三萜皂苷
收稿时间:2013-06-06

Advance on Chemical Constituents in Sophora flavescens
ZHANG Chi,MA Yue,GAO Hui-min,ZHANG Qi-wei and WANG Zhi-min. Advance on Chemical Constituents in Sophora flavescens[J]. China Journal of Experimental Traditional Medical Formulae, 2014, 20(4): 205-214
Authors:ZHANG Chi  MA Yue  GAO Hui-min  ZHANG Qi-wei  WANG Zhi-min
Affiliation:Institute of Chinese Materia Medica, China Academy of Chinese Medical sciences, Beijing 100700, China;Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical sciences, Beijing 100700, China;National Engineering Laboratory for Quality Control Technology of Chinese herbal Medicines, Beijing 100700, China
Abstract:To analyze and summarize the chemical constituents in Sophora flavescens, and provide some evidences for the comprehensive research and development of its resource. The previous literatures on the chemical constituents of S. flavescens were checked and then analyzed. The chemical studies were focused on the roots of this plant and the reported compounds mainly included alkaloids, flavonoids, triterpenoid saponins, lignans, phenolic acids, and etc. Among the isolated compounds, 41 alkaloids and 108 flavonoids were detailedly described and their structures were presented. However, few investigations were carried out on non-medicinal aerial parts of this plant, such as the stems, leaves, flowers, fruit and seeds. The further research on the aerial parts of S. flavescens is interest of the comprehensive development of plant resources.
Keywords:Sophora flavescens  chemical constituent  alkaloids  flavonoids  lignans  triterpenoid saponins
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