| Radiotherapy combined with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma - a prospective clinical trial |
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| 作者姓名： | Ling Cai Mengzhong Liu Xiushen Wang Mofa Gu Hui Liu Qun Li Nianji Cui Guohui Li Jinqing Li |
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| 作者单位： | [1]Department of Radiation Oncology and Medical Physics, The Cancer Center of Sun Yat-Sen University, Guangzhou 510060, China [2]Deparment of Hepatobiliary Tumor, The Cancer Center of Sun Yat-Sen University, Guangzhou 510060, China |
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| 摘 要： | Objective： This study evaluated the therapeutic effect of external beam radiotherapy （RT） combined with transcatheter arterial chemoembolization （TACE） on the patients with unresectable hepatocellular carcinoma （HCC）. Methods： From June 1994 to April 2002, 114 patients with unresectable HCC were nonrandomized prospectively stepped into our study. All patients received TACE as initial therapy, except 54 also received combination therapy with external beam therapy. Survival failure patterns were analyzed and compared between the two groups. Results： Overall survival rates in the patients in the radiotherapy group were 65%, 47%, 38% at 1,2, 3 years, respectively, improved over the non-radiotherapy group rates of 54%, 36.5%, 18% at 1, 2, 3 years, respectively. There was significant difference between two groups （P 〈 0.05）. The survival rates correlated with tumor size, number of tumors, and portal vein embolus. Conclusion： TACE combined with RT is a more effective treatment than TACE alone in patients with unresectable HCC.
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| 关 键 词： | 外照射治疗 肝动脉栓塞 手术切除 原发性肝癌 |
| 文章编号： | 10.1007/s10330-007-0144-y |
| 收稿时间： | 2007-08-20 |
| 修稿时间： | 2007-09-30 |
Radiotherapy combined with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma — a prospective clinical trial |
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| Ling Cai Mengzhong Liu Xiushen Wang Mofa Gu Hui Liu Qun Li Nianji Cui Guohui Li Jinqing Li.Radiotherapy combined with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma - a prospective clinical trial[J].The Chinese-German Journal of Clinical Oncology,2008,7(2):64-68. |
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| Authors: | Ling Cai Mengzhong Liu Xiushen Wang Mofa Gu Hui Liu Qun Li Nianji Cui Guohui Li Jinqing Li |
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| Institution: | (1) Department of Radiation Oncology and Medical Physics, The Cancer Center of Sun Yat-Sen University, Guangzhou, 510060, China;(2) Deparment of Hepatobiliary Tumor, The Cancer Center of Sun Yat-Sen University, Guangzhou, 510060, China |
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| Abstract: | Objective This study evaluated the therapeutic effect of external beam radiotherapy (RT) combined with transcatheter arterial chemoembolization
(TACE) on the patients with unresectable hepatocellular carcinoma (HCC).
Methods From June 1994 to April 2002, 114 patients with unresectable HCC were nonrandomized prospectively stepped into our study.
All patients received TACE as initial therapy, except 54 also received combination therapy with external beam therapy. Survival
failure patterns were analyzed and compared between the two groups.
Results Overall survival rates in the patients in the radiotherapy group were 65%, 47%, 38% at 1, 2, 3 years, respectively, improved
over the non-radiotherapy group rates of 54%, 36.5%, 18% at 1, 2, 3 years, respectively. There was significant difference
between two groups (P < 0.05). The survival rates correlated with tumor size, number of tumors, and portal vein embolus.
Conclusion TACE combined with RT is a more effective treatment than TACE alone in patients with unresectable HCC. |
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| Keywords: | radiotherapy transcatheter arterial chemoembolization hepatocellular carcinoma |
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