原发性高血压患者血清半胱氨酸、基质金属蛋白酶-9水平变化及其与颈动脉内膜中层厚度的相关性研究

目的 探讨原发性高血压(EH)患者血清同型半胱氨酸(Hcy)和基质金属蛋白酶-9(MMP-9)水平变化及其与颈动脉内膜中层厚度(IMT)的相关性.方法 选择100例EH患者作为研究对象,健康体检正常者30例作为对照组,用酶联免疫法(ELISA)检测血清Hcy、MMP-9水平,高分辨超声测定IMT作为大血管动脉粥样硬化程度的指标,分析Hcy、MMP-9与IMT之间的关系.结果 与对照组相比,高血压组血清Hcy、MMP-9水平均显著增高,IMT显著增厚(t=4.52,4.78、4.19,均P＜0.05).随着高血压分级水平的增高,IMT逐步增厚,颈动脉粥样硬化的程度逐渐加重(均P ＜0.05).血清Hcy、MMP-9与IMT呈正相关(r=0.352、0.326,均P＜0.05).结论 EH患者血清Hcy、MMP-9水平与IMT正相关,提示Hcy、MMP-9参与了EH致动脉粥样硬化的病理过程,且Hcy,MMP-9水平与高血压的严重程度有关.

Correlation of levels of serum Hcy and MMP-9 with carotid intima-media thickness in patients with essential hypertension

Objective To investigate the correlation of levels of Hyperhomocysteinemia （Hcy） and Matrix metalloproteinase-9 （ MMP-9 ） with intima-media thickness （IMT） in patients with essential hypertension （ EH ）. Methods 100 cases with EH and 30 healthy control subjects were selected. The levels of serum Hcy and MMP-9 were detected by enzyme-linked iramunosorbent assay （ELISA）. The IMT was detected by high-resolution uhrasound which as a index of large vessels atherosclerosis. Results The levels of serum Hcy and MMP-9 in EH group were significantly higher than those in control group（t = 4.52,4.78,4.19, all P 〈 0.05 ）. With the increased level of blood pressure classification IMT progressively thicker, and carotid atherosclerosis extent gradually increased, Hcy and MMP- 9 increased significantly. The levels of Hcy and MMP-9 were significantly higher showed significant diference（ all P 〈 0.05 ） ; the levels of serum Hcy and MMP-9 were positively correlated with IMT （ r = 0. 352,0. 326, all P 〈 0.05 ）. Conclusion The levels of serum Hcy and MMP-9 were positively correlated with IMT in EH patients,and it suggested that Hcy and MMP-9 participate the pathological process of arteriosclerosis.