健脾补肺汤联合化疗治疗晚期非小细胞肺癌的临床研究

目的 观察健脾补肺汤联合化疗治疗晚期非小细胞肺癌的近期疗效、生活质量及毒副反应.方法 60例晚期非小细胞肺癌患者按随机数字表分为治疗组和对照组,每组各30例,治疗组应用紫杉醇+顺铂(TP)化疗联合自拟健脾补肺汤,对照组单纯应用TP方案化疗.观察和比较两组的疗效、生活质量及肝肾功能损害.结果 两组缓解率差异无统计学意义(x2 =0.418,P＞0.05).治疗组生活质量改善率70％,高于对照组的40％(x2=6.545,P ＜0.05)；白细胞计数、血红蛋白、血小板减少及肝功能受损程度均小于对照组(Z=-2.516、-2.184、-2.059、-2.097,均P＜0.05).结论 健脾补肺汤联合化疗治疗晚期非小细胞肺癌患者不能提高疗效,但能减轻化疗引起的毒副反应,改善生活质量.

Clinical study on Jianpihufei decoction combined with chemotherapy in the treatment of advanced non small cell lung cancer

Objective To observe the short term curative effect,life quality, adverse reactions of Jianpibufei decoction combined with chemotherapy in the treatment of patients with advanced non small cell lung cenacer. Methods 60 patients with advanced non small cell lung cenacer were randomly divided into the treatment group and the control group, each group 30 cases. The treatment group was treated with TP scheme and Jianpibufei decoction. The control group was only treated with TP scheme. The effect, life quality and the injury of liver and kidney function was observed and compared between the two groups. Results The difference of the remission rate between the two groups had no statistical significance（ χ2 = 0. 418 ,P 〉 0.05 ）. The improving rate of life quality in the treatment group was 70% , and higher than that in the control group （40%） （χ2 = 6. 545,P 〈 0. 05 ）. The reduction of the white blood cell, the hemoglobin, platelet and the injury of liver function in the treatment group were lower than those in the control group obviously （ Z = - 2.516, - 2.184, - 2. 059, - 2. 097, all P 〈 0.05 ）. Conclusion Jianpibufei decoction combined with chemotherapy in the treatment of patients with advanced non small cell lung cenacer could not increase the effect, but could reduce the adverse reaction of the chemotherapy and improve the life quality of patients.